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Serum Glucose and Fructosamine in Relation to Risk of Cancer
BACKGROUND: Impaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556075/ https://www.ncbi.nlm.nih.gov/pubmed/23372798 http://dx.doi.org/10.1371/journal.pone.0054944 |
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author | Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Zethelius, Björn Wigertz, Annette Carroll, Paul Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Van Hemelrijck, Mieke |
author_facet | Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Zethelius, Björn Wigertz, Annette Carroll, Paul Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Van Hemelrijck, Mieke |
author_sort | Wulaningsih, Wahyu |
collection | PubMed |
description | BACKGROUND: Impaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of cancer. METHODS: We selected 11,998 persons (>20 years old) with four prospectively collected serum glucose and fructosamine measurements from the Apolipoprotein Mortality Risk (AMORIS) study. Multivariate Cox proportional hazards regression was used to assess standardized log of overall mean glucose and fructosamine in relation to cancer risk. Similar analyses were performed for tertiles of glucose and fructosamine and for different types of cancer. RESULTS: A positive trend was observed between standardized log overall mean glucose and overall cancer risk (HR = 1.08; 95% CI: 1.02–1.14). Including standardized log fructosamine in the model resulted in a stronger association between glucose and cancer risk and aninverse association between fructosamine and cancer risk (HR = 1.17; 95% CI: 1.08–1.26 and HR: 0.89; 95% CI: 0.82–0.96, respectively). Cancer risks were highest among those in the highest tertile of glucose and lowest tertile of fructosamine. Similar findings were observed for prostate, lung, and colorectal cancer while none observed for breast cancer. CONCLUSION: The contrasting effect between glucose, fructosamine, and cancer risk suggests the existence of distinct groups among those with impaired glucose metabolism, resulting in different cancer risks based on individual metabolic profiles. Further studies are needed to clarify whether glucose is a proxy of other lifestyle-related or metabolic factors. |
format | Online Article Text |
id | pubmed-3556075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35560752013-01-31 Serum Glucose and Fructosamine in Relation to Risk of Cancer Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Zethelius, Björn Wigertz, Annette Carroll, Paul Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Van Hemelrijck, Mieke PLoS One Research Article BACKGROUND: Impaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of cancer. METHODS: We selected 11,998 persons (>20 years old) with four prospectively collected serum glucose and fructosamine measurements from the Apolipoprotein Mortality Risk (AMORIS) study. Multivariate Cox proportional hazards regression was used to assess standardized log of overall mean glucose and fructosamine in relation to cancer risk. Similar analyses were performed for tertiles of glucose and fructosamine and for different types of cancer. RESULTS: A positive trend was observed between standardized log overall mean glucose and overall cancer risk (HR = 1.08; 95% CI: 1.02–1.14). Including standardized log fructosamine in the model resulted in a stronger association between glucose and cancer risk and aninverse association between fructosamine and cancer risk (HR = 1.17; 95% CI: 1.08–1.26 and HR: 0.89; 95% CI: 0.82–0.96, respectively). Cancer risks were highest among those in the highest tertile of glucose and lowest tertile of fructosamine. Similar findings were observed for prostate, lung, and colorectal cancer while none observed for breast cancer. CONCLUSION: The contrasting effect between glucose, fructosamine, and cancer risk suggests the existence of distinct groups among those with impaired glucose metabolism, resulting in different cancer risks based on individual metabolic profiles. Further studies are needed to clarify whether glucose is a proxy of other lifestyle-related or metabolic factors. Public Library of Science 2013-01-25 /pmc/articles/PMC3556075/ /pubmed/23372798 http://dx.doi.org/10.1371/journal.pone.0054944 Text en © 2013 Wulaningsih et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Zethelius, Björn Wigertz, Annette Carroll, Paul Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Van Hemelrijck, Mieke Serum Glucose and Fructosamine in Relation to Risk of Cancer |
title | Serum Glucose and Fructosamine in Relation to Risk of Cancer |
title_full | Serum Glucose and Fructosamine in Relation to Risk of Cancer |
title_fullStr | Serum Glucose and Fructosamine in Relation to Risk of Cancer |
title_full_unstemmed | Serum Glucose and Fructosamine in Relation to Risk of Cancer |
title_short | Serum Glucose and Fructosamine in Relation to Risk of Cancer |
title_sort | serum glucose and fructosamine in relation to risk of cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556075/ https://www.ncbi.nlm.nih.gov/pubmed/23372798 http://dx.doi.org/10.1371/journal.pone.0054944 |
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