Cargando…

Serum Glucose and Fructosamine in Relation to Risk of Cancer

BACKGROUND: Impaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of...

Descripción completa

Detalles Bibliográficos
Autores principales: Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Zethelius, Björn, Wigertz, Annette, Carroll, Paul, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Van Hemelrijck, Mieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556075/
https://www.ncbi.nlm.nih.gov/pubmed/23372798
http://dx.doi.org/10.1371/journal.pone.0054944
_version_ 1782257138460000256
author Wulaningsih, Wahyu
Holmberg, Lars
Garmo, Hans
Zethelius, Björn
Wigertz, Annette
Carroll, Paul
Lambe, Mats
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Van Hemelrijck, Mieke
author_facet Wulaningsih, Wahyu
Holmberg, Lars
Garmo, Hans
Zethelius, Björn
Wigertz, Annette
Carroll, Paul
Lambe, Mats
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Van Hemelrijck, Mieke
author_sort Wulaningsih, Wahyu
collection PubMed
description BACKGROUND: Impaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of cancer. METHODS: We selected 11,998 persons (>20 years old) with four prospectively collected serum glucose and fructosamine measurements from the Apolipoprotein Mortality Risk (AMORIS) study. Multivariate Cox proportional hazards regression was used to assess standardized log of overall mean glucose and fructosamine in relation to cancer risk. Similar analyses were performed for tertiles of glucose and fructosamine and for different types of cancer. RESULTS: A positive trend was observed between standardized log overall mean glucose and overall cancer risk (HR = 1.08; 95% CI: 1.02–1.14). Including standardized log fructosamine in the model resulted in a stronger association between glucose and cancer risk and aninverse association between fructosamine and cancer risk (HR = 1.17; 95% CI: 1.08–1.26 and HR: 0.89; 95% CI: 0.82–0.96, respectively). Cancer risks were highest among those in the highest tertile of glucose and lowest tertile of fructosamine. Similar findings were observed for prostate, lung, and colorectal cancer while none observed for breast cancer. CONCLUSION: The contrasting effect between glucose, fructosamine, and cancer risk suggests the existence of distinct groups among those with impaired glucose metabolism, resulting in different cancer risks based on individual metabolic profiles. Further studies are needed to clarify whether glucose is a proxy of other lifestyle-related or metabolic factors.
format Online
Article
Text
id pubmed-3556075
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35560752013-01-31 Serum Glucose and Fructosamine in Relation to Risk of Cancer Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Zethelius, Björn Wigertz, Annette Carroll, Paul Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Van Hemelrijck, Mieke PLoS One Research Article BACKGROUND: Impaired glucose metabolism has been linked with increased cancer risk, but the association between serum glucose and cancer risk remains unclear. We used repeated measurements of glucose and fructosamine to get more insight into the association between the glucose metabolism and risk of cancer. METHODS: We selected 11,998 persons (>20 years old) with four prospectively collected serum glucose and fructosamine measurements from the Apolipoprotein Mortality Risk (AMORIS) study. Multivariate Cox proportional hazards regression was used to assess standardized log of overall mean glucose and fructosamine in relation to cancer risk. Similar analyses were performed for tertiles of glucose and fructosamine and for different types of cancer. RESULTS: A positive trend was observed between standardized log overall mean glucose and overall cancer risk (HR = 1.08; 95% CI: 1.02–1.14). Including standardized log fructosamine in the model resulted in a stronger association between glucose and cancer risk and aninverse association between fructosamine and cancer risk (HR = 1.17; 95% CI: 1.08–1.26 and HR: 0.89; 95% CI: 0.82–0.96, respectively). Cancer risks were highest among those in the highest tertile of glucose and lowest tertile of fructosamine. Similar findings were observed for prostate, lung, and colorectal cancer while none observed for breast cancer. CONCLUSION: The contrasting effect between glucose, fructosamine, and cancer risk suggests the existence of distinct groups among those with impaired glucose metabolism, resulting in different cancer risks based on individual metabolic profiles. Further studies are needed to clarify whether glucose is a proxy of other lifestyle-related or metabolic factors. Public Library of Science 2013-01-25 /pmc/articles/PMC3556075/ /pubmed/23372798 http://dx.doi.org/10.1371/journal.pone.0054944 Text en © 2013 Wulaningsih et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wulaningsih, Wahyu
Holmberg, Lars
Garmo, Hans
Zethelius, Björn
Wigertz, Annette
Carroll, Paul
Lambe, Mats
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Van Hemelrijck, Mieke
Serum Glucose and Fructosamine in Relation to Risk of Cancer
title Serum Glucose and Fructosamine in Relation to Risk of Cancer
title_full Serum Glucose and Fructosamine in Relation to Risk of Cancer
title_fullStr Serum Glucose and Fructosamine in Relation to Risk of Cancer
title_full_unstemmed Serum Glucose and Fructosamine in Relation to Risk of Cancer
title_short Serum Glucose and Fructosamine in Relation to Risk of Cancer
title_sort serum glucose and fructosamine in relation to risk of cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556075/
https://www.ncbi.nlm.nih.gov/pubmed/23372798
http://dx.doi.org/10.1371/journal.pone.0054944
work_keys_str_mv AT wulaningsihwahyu serumglucoseandfructosamineinrelationtoriskofcancer
AT holmberglars serumglucoseandfructosamineinrelationtoriskofcancer
AT garmohans serumglucoseandfructosamineinrelationtoriskofcancer
AT zetheliusbjorn serumglucoseandfructosamineinrelationtoriskofcancer
AT wigertzannette serumglucoseandfructosamineinrelationtoriskofcancer
AT carrollpaul serumglucoseandfructosamineinrelationtoriskofcancer
AT lambemats serumglucoseandfructosamineinrelationtoriskofcancer
AT hammarniklas serumglucoseandfructosamineinrelationtoriskofcancer
AT walldiusgoran serumglucoseandfructosamineinrelationtoriskofcancer
AT jungneringmar serumglucoseandfructosamineinrelationtoriskofcancer
AT vanhemelrijckmieke serumglucoseandfructosamineinrelationtoriskofcancer