Cargando…

NLRP3 Inflammasome and MS/EAE

Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of...

Descripción completa

Detalles Bibliográficos
Autores principales: Inoue, Makoto, Shinohara, Mari L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556409/
https://www.ncbi.nlm.nih.gov/pubmed/23365725
http://dx.doi.org/10.1155/2013/859145
_version_ 1782257178472611840
author Inoue, Makoto
Shinohara, Mari L.
author_facet Inoue, Makoto
Shinohara, Mari L.
author_sort Inoue, Makoto
collection PubMed
description Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development.
format Online
Article
Text
id pubmed-3556409
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35564092013-01-30 NLRP3 Inflammasome and MS/EAE Inoue, Makoto Shinohara, Mari L. Autoimmune Dis Review Article Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development. Hindawi Publishing Corporation 2013 2013-01-08 /pmc/articles/PMC3556409/ /pubmed/23365725 http://dx.doi.org/10.1155/2013/859145 Text en Copyright © 2013 M. Inoue and M. L. Shinohara. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Inoue, Makoto
Shinohara, Mari L.
NLRP3 Inflammasome and MS/EAE
title NLRP3 Inflammasome and MS/EAE
title_full NLRP3 Inflammasome and MS/EAE
title_fullStr NLRP3 Inflammasome and MS/EAE
title_full_unstemmed NLRP3 Inflammasome and MS/EAE
title_short NLRP3 Inflammasome and MS/EAE
title_sort nlrp3 inflammasome and ms/eae
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556409/
https://www.ncbi.nlm.nih.gov/pubmed/23365725
http://dx.doi.org/10.1155/2013/859145
work_keys_str_mv AT inouemakoto nlrp3inflammasomeandmseae
AT shinoharamaril nlrp3inflammasomeandmseae