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NLRP3 Inflammasome and MS/EAE
Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556409/ https://www.ncbi.nlm.nih.gov/pubmed/23365725 http://dx.doi.org/10.1155/2013/859145 |
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author | Inoue, Makoto Shinohara, Mari L. |
author_facet | Inoue, Makoto Shinohara, Mari L. |
author_sort | Inoue, Makoto |
collection | PubMed |
description | Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development. |
format | Online Article Text |
id | pubmed-3556409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35564092013-01-30 NLRP3 Inflammasome and MS/EAE Inoue, Makoto Shinohara, Mari L. Autoimmune Dis Review Article Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development. Hindawi Publishing Corporation 2013 2013-01-08 /pmc/articles/PMC3556409/ /pubmed/23365725 http://dx.doi.org/10.1155/2013/859145 Text en Copyright © 2013 M. Inoue and M. L. Shinohara. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Inoue, Makoto Shinohara, Mari L. NLRP3 Inflammasome and MS/EAE |
title | NLRP3 Inflammasome and MS/EAE |
title_full | NLRP3 Inflammasome and MS/EAE |
title_fullStr | NLRP3 Inflammasome and MS/EAE |
title_full_unstemmed | NLRP3 Inflammasome and MS/EAE |
title_short | NLRP3 Inflammasome and MS/EAE |
title_sort | nlrp3 inflammasome and ms/eae |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556409/ https://www.ncbi.nlm.nih.gov/pubmed/23365725 http://dx.doi.org/10.1155/2013/859145 |
work_keys_str_mv | AT inouemakoto nlrp3inflammasomeandmseae AT shinoharamaril nlrp3inflammasomeandmseae |