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Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease
OBJECTIVE: To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening. METHODS: A systematic review and meta-analysis of risk factors for PD. RESULTS: The strongest associations with later diagnosis of PD were fou...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556649/ https://www.ncbi.nlm.nih.gov/pubmed/23071076 http://dx.doi.org/10.1002/ana.23687 |
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author | Noyce, Alastair J Bestwick, Jonathan P Silveira-Moriyama, Laura Hawkes, Christopher H Giovannoni, Gavin Lees, Andrew J Schrag, Anette |
author_facet | Noyce, Alastair J Bestwick, Jonathan P Silveira-Moriyama, Laura Hawkes, Christopher H Giovannoni, Gavin Lees, Andrew J Schrag, Anette |
author_sort | Noyce, Alastair J |
collection | PubMed |
description | OBJECTIVE: To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening. METHODS: A systematic review and meta-analysis of risk factors for PD. RESULTS: The strongest associations with later diagnosis of PD were found for having a first-degree or any relative with PD (odds ratio [OR], 3.23; 95% confidence interval [CI], 2.65–3.93 and OR, 4.45; 95% CI, 3.39–5.83) or any relative with tremor (OR, 2.74; 95% CI, 2.10–3.57), constipation (relative risk [RR], 2.34; 95% CI, 1.55–3.53), or lack of smoking history (current vs never: RR, 0.44; 95% CI, 0.39–0.50), each at least doubling the risk of PD. Further positive significant associations were found for history of anxiety or depression, pesticide exposure, head injury, rural living, beta-blockers, farming occupation, and well-water drinking, and negative significant associations were found for coffee drinking, hypertension, nonsteroidal anti-inflammatory drugs, calcium channel blockers, and alcohol, but not for diabetes mellitus, cancer, oral contraceptive pill use, surgical menopause, hormone replacement therapy, statins, acetaminophen/paracetamol, aspirin, tea drinking, history of general anesthesia, or gastric ulcers. In the systematic review, additional associations included negative associations with raised serum urate, and single studies or studies with conflicting results. INTERPRETATION: The strongest risk factors associated with later PD diagnosis are having a family history of PD or tremor, a history of constipation, and lack of smoking history. Further factors also but less strongly contribute to risk of PD diagnosis or, as some premotor symptoms, require further standardized studies to demonstrate the magnitude of risk associated with them. ANN NEUROL 2012 |
format | Online Article Text |
id | pubmed-3556649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Wiley Subscription Services, Inc., A Wiley Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-35566492013-01-28 Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease Noyce, Alastair J Bestwick, Jonathan P Silveira-Moriyama, Laura Hawkes, Christopher H Giovannoni, Gavin Lees, Andrew J Schrag, Anette Ann Neurol Original Articles OBJECTIVE: To evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening. METHODS: A systematic review and meta-analysis of risk factors for PD. RESULTS: The strongest associations with later diagnosis of PD were found for having a first-degree or any relative with PD (odds ratio [OR], 3.23; 95% confidence interval [CI], 2.65–3.93 and OR, 4.45; 95% CI, 3.39–5.83) or any relative with tremor (OR, 2.74; 95% CI, 2.10–3.57), constipation (relative risk [RR], 2.34; 95% CI, 1.55–3.53), or lack of smoking history (current vs never: RR, 0.44; 95% CI, 0.39–0.50), each at least doubling the risk of PD. Further positive significant associations were found for history of anxiety or depression, pesticide exposure, head injury, rural living, beta-blockers, farming occupation, and well-water drinking, and negative significant associations were found for coffee drinking, hypertension, nonsteroidal anti-inflammatory drugs, calcium channel blockers, and alcohol, but not for diabetes mellitus, cancer, oral contraceptive pill use, surgical menopause, hormone replacement therapy, statins, acetaminophen/paracetamol, aspirin, tea drinking, history of general anesthesia, or gastric ulcers. In the systematic review, additional associations included negative associations with raised serum urate, and single studies or studies with conflicting results. INTERPRETATION: The strongest risk factors associated with later PD diagnosis are having a family history of PD or tremor, a history of constipation, and lack of smoking history. Further factors also but less strongly contribute to risk of PD diagnosis or, as some premotor symptoms, require further standardized studies to demonstrate the magnitude of risk associated with them. ANN NEUROL 2012 Wiley Subscription Services, Inc., A Wiley Company 2012-12 2012-10-15 /pmc/articles/PMC3556649/ /pubmed/23071076 http://dx.doi.org/10.1002/ana.23687 Text en Copyright © 2012 American Neurological Association http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Original Articles Noyce, Alastair J Bestwick, Jonathan P Silveira-Moriyama, Laura Hawkes, Christopher H Giovannoni, Gavin Lees, Andrew J Schrag, Anette Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease |
title | Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease |
title_full | Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease |
title_fullStr | Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease |
title_full_unstemmed | Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease |
title_short | Meta-Analysis of Early Nonmotor Features and Risk Factors for Parkinson Disease |
title_sort | meta-analysis of early nonmotor features and risk factors for parkinson disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556649/ https://www.ncbi.nlm.nih.gov/pubmed/23071076 http://dx.doi.org/10.1002/ana.23687 |
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