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Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being elucidated. Here, we demonstrate that endoxifen-me...

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Detalles Bibliográficos
Autores principales: Hawse, John R., Subramaniam, Malayannan, Cicek, Muzaffer, Wu, Xianglin, Gingery, Anne, Grygo, Sarah B., Sun, Zhifu, Pitel, Kevin S., Lingle, Wilma L., Goetz, Matthew P., Ingle, James N., Spelsberg, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557294/
https://www.ncbi.nlm.nih.gov/pubmed/23382923
http://dx.doi.org/10.1371/journal.pone.0054613

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