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Myoepithelioma breast: clinically masquerading as breast carcinoma

Pure myoepithelioma of breast is an extremely rare tumor. Only a few cases have been reported in the literature so far. A 30-year old female presented with a large fungating mass arising from the areolar region of her right breast of six months duration. A clinical diagnosis of breast carcinoma was...

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Autores principales: Thakur, Brijesh, Misra, Vatsala, Dhingra, Vishal, Chauhan, Smita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557564/
https://www.ncbi.nlm.nih.gov/pubmed/23372914
http://dx.doi.org/10.4081/rt.2012.e50
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author Thakur, Brijesh
Misra, Vatsala
Dhingra, Vishal
Chauhan, Smita
author_facet Thakur, Brijesh
Misra, Vatsala
Dhingra, Vishal
Chauhan, Smita
author_sort Thakur, Brijesh
collection PubMed
description Pure myoepithelioma of breast is an extremely rare tumor. Only a few cases have been reported in the literature so far. A 30-year old female presented with a large fungating mass arising from the areolar region of her right breast of six months duration. A clinical diagnosis of breast carcinoma was made and a mastectomy was performed. The specimen measured 23×22×9 cm with attached skin, and showed a large white ulcerated growth with areas of necrosis and hemorrhage. No normal breast tissue, nipple or areolar region was seen. Histopathological examination showed oval to spindle cells arranged in fascicles and bundles with whorling pattern in places showing mild pleomorphism with oval to spindle-shaped vesicular nuclei, prominent eosinophilic nucleoli, eosinophilic cytoplasm and clear cell changes in places, along with perivascular hyalinization and collagenization. Differential diagnosis of pleomorphic hyalinizing angiectatic tumor, solitary fibrous tumor, perivascular epithelioid cell tumor, mammary type myofibroblastic tumor and myoepithelioma were all considered. Immunohistochemistry for vimentin, smooth muscle actin, calponin, caldesmon, p63, epithelial membrane antigen, S-100, CD-31, CD-34, muscle specific antigen, myogenin, desmin, and pancytokeratin was carried out. On the basis of positive staining for vimentin, actin, p63 (nuclear), calponin and caldesmon (focal), a final diagnosis of myoepithelioma was considered; however, cytokeratin negativity was an unusual finding. This case was considered worthy of documentation because of its rarity, and because it highlights the importance of proper clinical examination and radiological examination to prevent misdiagnosis.
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spelling pubmed-35575642013-01-31 Myoepithelioma breast: clinically masquerading as breast carcinoma Thakur, Brijesh Misra, Vatsala Dhingra, Vishal Chauhan, Smita Rare Tumors Case Report Pure myoepithelioma of breast is an extremely rare tumor. Only a few cases have been reported in the literature so far. A 30-year old female presented with a large fungating mass arising from the areolar region of her right breast of six months duration. A clinical diagnosis of breast carcinoma was made and a mastectomy was performed. The specimen measured 23×22×9 cm with attached skin, and showed a large white ulcerated growth with areas of necrosis and hemorrhage. No normal breast tissue, nipple or areolar region was seen. Histopathological examination showed oval to spindle cells arranged in fascicles and bundles with whorling pattern in places showing mild pleomorphism with oval to spindle-shaped vesicular nuclei, prominent eosinophilic nucleoli, eosinophilic cytoplasm and clear cell changes in places, along with perivascular hyalinization and collagenization. Differential diagnosis of pleomorphic hyalinizing angiectatic tumor, solitary fibrous tumor, perivascular epithelioid cell tumor, mammary type myofibroblastic tumor and myoepithelioma were all considered. Immunohistochemistry for vimentin, smooth muscle actin, calponin, caldesmon, p63, epithelial membrane antigen, S-100, CD-31, CD-34, muscle specific antigen, myogenin, desmin, and pancytokeratin was carried out. On the basis of positive staining for vimentin, actin, p63 (nuclear), calponin and caldesmon (focal), a final diagnosis of myoepithelioma was considered; however, cytokeratin negativity was an unusual finding. This case was considered worthy of documentation because of its rarity, and because it highlights the importance of proper clinical examination and radiological examination to prevent misdiagnosis. PAGEPress Publications 2012-12-17 /pmc/articles/PMC3557564/ /pubmed/23372914 http://dx.doi.org/10.4081/rt.2012.e50 Text en ©Copyright B. Thakur et al., 2012 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy
spellingShingle Case Report
Thakur, Brijesh
Misra, Vatsala
Dhingra, Vishal
Chauhan, Smita
Myoepithelioma breast: clinically masquerading as breast carcinoma
title Myoepithelioma breast: clinically masquerading as breast carcinoma
title_full Myoepithelioma breast: clinically masquerading as breast carcinoma
title_fullStr Myoepithelioma breast: clinically masquerading as breast carcinoma
title_full_unstemmed Myoepithelioma breast: clinically masquerading as breast carcinoma
title_short Myoepithelioma breast: clinically masquerading as breast carcinoma
title_sort myoepithelioma breast: clinically masquerading as breast carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557564/
https://www.ncbi.nlm.nih.gov/pubmed/23372914
http://dx.doi.org/10.4081/rt.2012.e50
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