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Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome

Oxygenation is an important component of the tumour microenvironment, having a significant impact on the progression and management of cancer. Theoretical determination of tissue oxygenation through simulations of the oxygen transport process is a powerful tool to characterise the spatial distributi...

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Detalles Bibliográficos
Autores principales: Toma-Dasu, Iuliana, Dasu, Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557613/
https://www.ncbi.nlm.nih.gov/pubmed/23401721
http://dx.doi.org/10.1155/2013/141087
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author Toma-Dasu, Iuliana
Dasu, Alexandru
author_facet Toma-Dasu, Iuliana
Dasu, Alexandru
author_sort Toma-Dasu, Iuliana
collection PubMed
description Oxygenation is an important component of the tumour microenvironment, having a significant impact on the progression and management of cancer. Theoretical determination of tissue oxygenation through simulations of the oxygen transport process is a powerful tool to characterise the spatial distribution of oxygen on the microscopic scale and its dynamics and to study its impact on the response to radiation. Accurate modelling of tumour oxygenation must take into account important aspects that are specific to tumours, making the quantitative characterisation of oxygenation rather difficult. This paper aims to discuss the important aspects of modelling tumour oxygenation, reoxygenation, and implications for treatment.
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spelling pubmed-35576132013-02-11 Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome Toma-Dasu, Iuliana Dasu, Alexandru Comput Math Methods Med Review Article Oxygenation is an important component of the tumour microenvironment, having a significant impact on the progression and management of cancer. Theoretical determination of tissue oxygenation through simulations of the oxygen transport process is a powerful tool to characterise the spatial distribution of oxygen on the microscopic scale and its dynamics and to study its impact on the response to radiation. Accurate modelling of tumour oxygenation must take into account important aspects that are specific to tumours, making the quantitative characterisation of oxygenation rather difficult. This paper aims to discuss the important aspects of modelling tumour oxygenation, reoxygenation, and implications for treatment. Hindawi Publishing Corporation 2013 2013-01-14 /pmc/articles/PMC3557613/ /pubmed/23401721 http://dx.doi.org/10.1155/2013/141087 Text en Copyright © 2013 I. Toma-Dasu and A. Dasu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Toma-Dasu, Iuliana
Dasu, Alexandru
Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome
title Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome
title_full Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome
title_fullStr Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome
title_full_unstemmed Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome
title_short Modelling Tumour Oxygenation, Reoxygenation and Implications on Treatment Outcome
title_sort modelling tumour oxygenation, reoxygenation and implications on treatment outcome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557613/
https://www.ncbi.nlm.nih.gov/pubmed/23401721
http://dx.doi.org/10.1155/2013/141087
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