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Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants
Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557621/ https://www.ncbi.nlm.nih.gov/pubmed/23401695 http://dx.doi.org/10.1155/2013/874726 |
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author | Nair, Vrinda Soraisham, Amuchou S. |
author_facet | Nair, Vrinda Soraisham, Amuchou S. |
author_sort | Nair, Vrinda |
collection | PubMed |
description | Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants. |
format | Online Article Text |
id | pubmed-3557621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35576212013-02-11 Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants Nair, Vrinda Soraisham, Amuchou S. Int J Pediatr Review Article Nosocomial sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay. Prevention of sepsis especially in the preterm infants in the neonatal intensive care unit remains a major challenge. The gastrointestinal tract is an important source of potential pathogens causing nosocomial sepsis as the immature intestinal epithelium can permit translocation of bacteria and yeast. The intestinal tract and its microflora play an important role in the immunity. Altering the gut microflora has been extensively studied for immunomodulation in preterm infants. Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics have been used for prevention and treatment of various medical conditions in children and adults. Studies on probiotics in premature infants have focused on normalizing intestinal flora, improvement in feeding intolerance, prevention of necrotizing enterocolitis and sepsis. In this paper, we discuss the intestinal bacterial colonization pattern; the rational for probiotics and prebiotic therapy with special focus on the prevention of nosocomial sepsis in preterm infants. Hindawi Publishing Corporation 2013 2013-01-14 /pmc/articles/PMC3557621/ /pubmed/23401695 http://dx.doi.org/10.1155/2013/874726 Text en Copyright © 2013 V. Nair and A. S. Soraisham. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nair, Vrinda Soraisham, Amuchou S. Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
title | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
title_full | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
title_fullStr | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
title_full_unstemmed | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
title_short | Probiotics and Prebiotics: Role in Prevention of Nosocomial Sepsis in Preterm Infants |
title_sort | probiotics and prebiotics: role in prevention of nosocomial sepsis in preterm infants |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557621/ https://www.ncbi.nlm.nih.gov/pubmed/23401695 http://dx.doi.org/10.1155/2013/874726 |
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