Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1

Pituitary adenylate cyclase-activating peptide (PACAP) is a neuroprotective peptide which exerts its effects mainly through the cAMP-protein kinase A (PKA) pathway. Here, we show that in cortical neurons, PACAP-induced PKA signaling exerts a major part of its neuroprotective effects indirectly, by t...

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Detalles Bibliográficos
Autores principales: Baxter, Paul S, Martel, Marc-Andre, McMahon, Aoife, Kind, Peter C, Hardingham, Giles E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557719/
https://www.ncbi.nlm.nih.gov/pubmed/21623792
http://dx.doi.org/10.1111/j.1471-4159.2011.07330.x

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