Alkylation induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

O(6)-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly half of sporadic colorectal cancers, suggesting that this loss maybe causal. Using mi...

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Detalles Bibliográficos
Autores principales: Bugni, James M., Meira, Lisiane B., Samson, Leona D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557788/
https://www.ncbi.nlm.nih.gov/pubmed/19029948
http://dx.doi.org/10.1038/onc.2008.426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557788/
https://www.ncbi.nlm.nih.gov/pubmed/19029948
http://dx.doi.org/10.1038/onc.2008.426

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