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Alkylation induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

O(6)-methylguanine DNA methyltransferase (MGMT) suppresses mutations and cell death that result from alkylation damage. MGMT expression is lost by epigenetic silencing in a variety of human cancers including nearly half of sporadic colorectal cancers, suggesting that this loss maybe causal. Using mi...

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Detalles Bibliográficos
Autores principales:	Bugni, James M., Meira, Lisiane B., Samson, Leona D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557788/ https://www.ncbi.nlm.nih.gov/pubmed/19029948 http://dx.doi.org/10.1038/onc.2008.426

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