Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to rele...

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Autores principales: Pournaras, Spyros, Ntokou, Eleni, Zarkotou, Olympia, Ranellou, Kyriaki, Themeli-Digalaki, Katerina, Stathopoulos, Constantinos, Tsakris, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557967/
https://www.ncbi.nlm.nih.gov/pubmed/23260390
http://dx.doi.org/10.3201/eid1901.111527
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author Pournaras, Spyros
Ntokou, Eleni
Zarkotou, Olympia
Ranellou, Kyriaki
Themeli-Digalaki, Katerina
Stathopoulos, Constantinos
Tsakris, Athanassios
author_facet Pournaras, Spyros
Ntokou, Eleni
Zarkotou, Olympia
Ranellou, Kyriaki
Themeli-Digalaki, Katerina
Stathopoulos, Constantinos
Tsakris, Athanassios
author_sort Pournaras, Spyros
collection PubMed
description We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.
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spelling pubmed-35579672013-02-04 Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates Pournaras, Spyros Ntokou, Eleni Zarkotou, Olympia Ranellou, Kyriaki Themeli-Digalaki, Katerina Stathopoulos, Constantinos Tsakris, Athanassios Emerg Infect Dis Dispatch We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence. Centers for Disease Control and Prevention 2013-01 /pmc/articles/PMC3557967/ /pubmed/23260390 http://dx.doi.org/10.3201/eid1901.111527 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Pournaras, Spyros
Ntokou, Eleni
Zarkotou, Olympia
Ranellou, Kyriaki
Themeli-Digalaki, Katerina
Stathopoulos, Constantinos
Tsakris, Athanassios
Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_full Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_fullStr Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_full_unstemmed Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_short Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_sort linezolid dependence in staphylococcus epidermidis bloodstream isolates
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557967/
https://www.ncbi.nlm.nih.gov/pubmed/23260390
http://dx.doi.org/10.3201/eid1901.111527
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