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Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed

Musa sapientum (M.sapientum) commonly known as ‘banana’ is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sap...

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Autores principales: Hossain, M. Sarowar, Alam, M. Badrul, Asadujjaman, M., Zahan, Ronok, Islam, M. Monirul, Mazumder, M. Ehsanul H., Haque, Md. Ekramul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558179/
https://www.ncbi.nlm.nih.gov/pubmed/23407989
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author Hossain, M. Sarowar
Alam, M. Badrul
Asadujjaman, M.
Zahan, Ronok
Islam, M. Monirul
Mazumder, M. Ehsanul H.
Haque, Md. Ekramul
author_facet Hossain, M. Sarowar
Alam, M. Badrul
Asadujjaman, M.
Zahan, Ronok
Islam, M. Monirul
Mazumder, M. Ehsanul H.
Haque, Md. Ekramul
author_sort Hossain, M. Sarowar
collection PubMed
description Musa sapientum (M.sapientum) commonly known as ‘banana’ is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sapientum seed (MMSS). The extract was studied for antidiarrheal property using castor oil and magnesium sulfate induced diarrheal model and charcoal induced gastrointestinal motility test in mice. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as nitric oxide (NO) and assessment of reducing power were used to evaluate antioxidant potential of MMSS. In addition, disc diffusion methods were used for antibacterial assay using various diarrheal induced bacterial strains. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. At the same doses, the extracts significantly (p<0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. In DPPH and NO scavenging method, MMSS showed good antioxidant potentiality in a dose dependent manner with the IC(50) value of 12.32±0.33 µg/ml and 18.96±1.01 µg/ml, respectively with a significant (p<0.001) good reducing power. The extract also displayed strong anti-bacterial effect against when tested against Escherichia coli, Shigella dysenteriae, and Pseudomonas aeruginosa. Altogether, these results suggest that the MMSS could be used as a potential antidiarrheal agent along with its antioxidant and antibacterial potentiality.
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spelling pubmed-35581792013-02-13 Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed Hossain, M. Sarowar Alam, M. Badrul Asadujjaman, M. Zahan, Ronok Islam, M. Monirul Mazumder, M. Ehsanul H. Haque, Md. Ekramul Avicenna J Med Biotechnol Original Article Musa sapientum (M.sapientum) commonly known as ‘banana’ is widely used in Bangladeshi folk medicine for the treatment of various ailments including diarrhea. Hence, the present study was designed to investigate antidiarrheal, antioxidant and antibacterial potential of the methanolic extract of M.sapientum seed (MMSS). The extract was studied for antidiarrheal property using castor oil and magnesium sulfate induced diarrheal model and charcoal induced gastrointestinal motility test in mice. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as nitric oxide (NO) and assessment of reducing power were used to evaluate antioxidant potential of MMSS. In addition, disc diffusion methods were used for antibacterial assay using various diarrheal induced bacterial strains. At the doses of 100 and 200 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test animals throughout the study period. At the same doses, the extracts significantly (p<0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. In DPPH and NO scavenging method, MMSS showed good antioxidant potentiality in a dose dependent manner with the IC(50) value of 12.32±0.33 µg/ml and 18.96±1.01 µg/ml, respectively with a significant (p<0.001) good reducing power. The extract also displayed strong anti-bacterial effect against when tested against Escherichia coli, Shigella dysenteriae, and Pseudomonas aeruginosa. Altogether, these results suggest that the MMSS could be used as a potential antidiarrheal agent along with its antioxidant and antibacterial potentiality. Avicenna Research Institute 2011 /pmc/articles/PMC3558179/ /pubmed/23407989 Text en Copyright © 2011 Avicenna Research Institute http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Hossain, M. Sarowar
Alam, M. Badrul
Asadujjaman, M.
Zahan, Ronok
Islam, M. Monirul
Mazumder, M. Ehsanul H.
Haque, Md. Ekramul
Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed
title Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed
title_full Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed
title_fullStr Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed
title_full_unstemmed Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed
title_short Antidiarrheal, Antioxidant and Antimicrobial Activities of the Musa sapientum Seed
title_sort antidiarrheal, antioxidant and antimicrobial activities of the musa sapientum seed
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558179/
https://www.ncbi.nlm.nih.gov/pubmed/23407989
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