Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA

Cell free DNA (cfDNA) is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. Identification of circulating cancer related DNA molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. For this revi...

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Detalles Bibliográficos
Autores principales: Ghorbian, Saeid, Ardekani, Ali M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558201/
https://www.ncbi.nlm.nih.gov/pubmed/23407878
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author Ghorbian, Saeid
Ardekani, Ali M.
author_facet Ghorbian, Saeid
Ardekani, Ali M.
author_sort Ghorbian, Saeid
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description Cell free DNA (cfDNA) is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. Identification of circulating cancer related DNA molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. For this review, study selection and data extraction were performed by the authors. Detection of point mutations, microsatellite alterations, DNA hypermethylations and losses of heterozygosity in circulating cell free DNA have been characterized in esophagus cancer. Application of circulating cell free DNA as a biomarker, provide the best opportunity for constructing non-invasive tests for early detection, prognosis and management of cancer patients, after therapy in many types of cancer.
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spelling pubmed-35582012013-02-13 Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA Ghorbian, Saeid Ardekani, Ali M. Avicenna J Med Biotechnol Review Article Cell free DNA (cfDNA) is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. Identification of circulating cancer related DNA molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. For this review, study selection and data extraction were performed by the authors. Detection of point mutations, microsatellite alterations, DNA hypermethylations and losses of heterozygosity in circulating cell free DNA have been characterized in esophagus cancer. Application of circulating cell free DNA as a biomarker, provide the best opportunity for constructing non-invasive tests for early detection, prognosis and management of cancer patients, after therapy in many types of cancer. Avicenna Research Institute 2012 /pmc/articles/PMC3558201/ /pubmed/23407878 Text en Copyright © 2012 Avicenna Research Institute http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Review Article
Ghorbian, Saeid
Ardekani, Ali M.
Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA
title Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA
title_full Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA
title_fullStr Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA
title_full_unstemmed Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA
title_short Non-Invasive Detection of Esophageal Cancer using Genetic Changes in Circulating Cell-Free DNA
title_sort non-invasive detection of esophageal cancer using genetic changes in circulating cell-free dna
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558201/
https://www.ncbi.nlm.nih.gov/pubmed/23407878
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