De novo assembly of bacterial genomes from single cells

Whole genome amplification by the multiple displacement amplification (MDA) method allows sequencing of genomes from single cells of bacteria that cannot be cultured. However, genome assembly is challenging because of highly non-uniform read coverage generated by MDA. We describe an improved assembl...

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Detalles Bibliográficos
Autores principales: Chitsaz, Hamidreza, Yee-Greenbaum, Joyclyn L., Tesler, Glenn, Lombardo, Mary-Jane, Dupont, Christopher L., Badger, Jonathan H., Novotny, Mark, Rusch, Douglas B., Fraser, Louise J., Gormley, Niall A., Schulz-Trieglaff, Ole, Smith, Geoffrey P., Evers, Dirk J., Pevzner, Pavel A., Lasken, Roger S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558281/
https://www.ncbi.nlm.nih.gov/pubmed/21926975
http://dx.doi.org/10.1038/nbt.1966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558281/
https://www.ncbi.nlm.nih.gov/pubmed/21926975
http://dx.doi.org/10.1038/nbt.1966

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