An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia

BACKGROUND: Onset of Henoch-Schönlein purpura (HSP) in middle age is uncommon, and adults with renal or gastrointestinal involvement present with more severe disease than do similar pediatric patients. CASE PRESENTATION: We present the case of a 69-year-old male with HSP who, after treatment with st...

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Autores principales: Oshikata, Chiyako, Tsurikisawa, Naomi, Takigawa, Masakazu, Omori, Tomoko, Sugano, Satoshi, Tsuburai, Takahiro, Mitomi, Hiroyuki, Takemura, Tamiko, Akiyama, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558347/
https://www.ncbi.nlm.nih.gov/pubmed/23343144
http://dx.doi.org/10.1186/1756-0500-6-26
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author Oshikata, Chiyako
Tsurikisawa, Naomi
Takigawa, Masakazu
Omori, Tomoko
Sugano, Satoshi
Tsuburai, Takahiro
Mitomi, Hiroyuki
Takemura, Tamiko
Akiyama, Kazuo
author_facet Oshikata, Chiyako
Tsurikisawa, Naomi
Takigawa, Masakazu
Omori, Tomoko
Sugano, Satoshi
Tsuburai, Takahiro
Mitomi, Hiroyuki
Takemura, Tamiko
Akiyama, Kazuo
author_sort Oshikata, Chiyako
collection PubMed
description BACKGROUND: Onset of Henoch-Schönlein purpura (HSP) in middle age is uncommon, and adults with renal or gastrointestinal involvement present with more severe disease than do similar pediatric patients. CASE PRESENTATION: We present the case of a 69-year-old male with HSP who, after treatment with steroids, cyclophosphamide, and continuous intravenous prostaglandin E1 (PGE1), died as a result of severe gastrointestinal involvement with non-occlusive mesenteric ischemia (NOMI). Vascular narrowing associated with the NOMI improved after catheter injection of PGE1 and prednisolone, but the patient died of bleeding from an exposed small vessel. At autopsy there was no active vasculitis in the jejunal submucosa. CONCLUSION: Treatment with PGE1 and prednisolone might improve small-vessel vasculitis associated with NOMI.
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spelling pubmed-35583472013-01-31 An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia Oshikata, Chiyako Tsurikisawa, Naomi Takigawa, Masakazu Omori, Tomoko Sugano, Satoshi Tsuburai, Takahiro Mitomi, Hiroyuki Takemura, Tamiko Akiyama, Kazuo BMC Res Notes Case Report BACKGROUND: Onset of Henoch-Schönlein purpura (HSP) in middle age is uncommon, and adults with renal or gastrointestinal involvement present with more severe disease than do similar pediatric patients. CASE PRESENTATION: We present the case of a 69-year-old male with HSP who, after treatment with steroids, cyclophosphamide, and continuous intravenous prostaglandin E1 (PGE1), died as a result of severe gastrointestinal involvement with non-occlusive mesenteric ischemia (NOMI). Vascular narrowing associated with the NOMI improved after catheter injection of PGE1 and prednisolone, but the patient died of bleeding from an exposed small vessel. At autopsy there was no active vasculitis in the jejunal submucosa. CONCLUSION: Treatment with PGE1 and prednisolone might improve small-vessel vasculitis associated with NOMI. BioMed Central 2013-01-23 /pmc/articles/PMC3558347/ /pubmed/23343144 http://dx.doi.org/10.1186/1756-0500-6-26 Text en Copyright ©2013 Oshikata et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Oshikata, Chiyako
Tsurikisawa, Naomi
Takigawa, Masakazu
Omori, Tomoko
Sugano, Satoshi
Tsuburai, Takahiro
Mitomi, Hiroyuki
Takemura, Tamiko
Akiyama, Kazuo
An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia
title An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia
title_full An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia
title_fullStr An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia
title_full_unstemmed An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia
title_short An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia
title_sort adult patient with henoch-schönlein purpura and non-occlusive mesenteric ischemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558347/
https://www.ncbi.nlm.nih.gov/pubmed/23343144
http://dx.doi.org/10.1186/1756-0500-6-26
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