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Role of reactive nitrogen species in male infertility
Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen species (ROS). Physiological levels of ROS are necessary to maintain the reproductive functions such as cell signaling, tight junction regulation, production of hormones, capacitation, acrosomal reaction, sper...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558381/ https://www.ncbi.nlm.nih.gov/pubmed/23241221 http://dx.doi.org/10.1186/1477-7827-10-109 |
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author | Doshi, Sejal B Khullar, Karishma Sharma, Rakesh K Agarwal, Ashok |
author_facet | Doshi, Sejal B Khullar, Karishma Sharma, Rakesh K Agarwal, Ashok |
author_sort | Doshi, Sejal B |
collection | PubMed |
description | Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen species (ROS). Physiological levels of ROS are necessary to maintain the reproductive functions such as cell signaling, tight junction regulation, production of hormones, capacitation, acrosomal reaction, sperm motility, and zona pellucida binding. However, an excess of RNS can adversely affect reproductive potential by causing testicular dysfunction, decreased gonadotropin secretion, and abnormal semen parameters. Because such levels of RNS have been demonstrated in males with fertility problems and routine semen analysis has not been able to accurately predict IVF outcomes, it is imperative that novel strategies be developed in order to both assess and treat oxidative stress. This article describes both physiological and pathological roles of this unique subset of ROS. |
format | Online Article Text |
id | pubmed-3558381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35583812013-01-31 Role of reactive nitrogen species in male infertility Doshi, Sejal B Khullar, Karishma Sharma, Rakesh K Agarwal, Ashok Reprod Biol Endocrinol Review Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen species (ROS). Physiological levels of ROS are necessary to maintain the reproductive functions such as cell signaling, tight junction regulation, production of hormones, capacitation, acrosomal reaction, sperm motility, and zona pellucida binding. However, an excess of RNS can adversely affect reproductive potential by causing testicular dysfunction, decreased gonadotropin secretion, and abnormal semen parameters. Because such levels of RNS have been demonstrated in males with fertility problems and routine semen analysis has not been able to accurately predict IVF outcomes, it is imperative that novel strategies be developed in order to both assess and treat oxidative stress. This article describes both physiological and pathological roles of this unique subset of ROS. BioMed Central 2012-12-15 /pmc/articles/PMC3558381/ /pubmed/23241221 http://dx.doi.org/10.1186/1477-7827-10-109 Text en Copyright ©2012 Doshi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Doshi, Sejal B Khullar, Karishma Sharma, Rakesh K Agarwal, Ashok Role of reactive nitrogen species in male infertility |
title | Role of reactive nitrogen species in male infertility |
title_full | Role of reactive nitrogen species in male infertility |
title_fullStr | Role of reactive nitrogen species in male infertility |
title_full_unstemmed | Role of reactive nitrogen species in male infertility |
title_short | Role of reactive nitrogen species in male infertility |
title_sort | role of reactive nitrogen species in male infertility |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558381/ https://www.ncbi.nlm.nih.gov/pubmed/23241221 http://dx.doi.org/10.1186/1477-7827-10-109 |
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