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MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systemati...

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Detalles Bibliográficos
Autores principales:	Lin, Shibo, Hoffmann, Katrin, Xiao, Zhi, Jin, Nan, Galli, Uwe, Mohr, Elvira, Büchler, Markus W, Schemmer, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558388/ https://www.ncbi.nlm.nih.gov/pubmed/23320839 http://dx.doi.org/10.1186/1475-2867-13-3

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