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NOD-scid IL2R γ(null) mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways

BACKGROUND: Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific activation mechanisms and the immunological background of the animals which markedly differs from the genetically heterogeneous and often...

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Detalles Bibliográficos
Autores principales:	Zadeh-Khorasani, Maryam, Nolte, Thomas, Mueller, Thomas D, Pechlivanis, Markos, Rueff, Franziska, Wollenberg, Andreas, Fricker, Gert, Wolf, Eckhard, Siebeck, Matthias, Gropp, Roswitha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558457/ https://www.ncbi.nlm.nih.gov/pubmed/23294516 http://dx.doi.org/10.1186/1479-5876-11-4

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