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Mutation in E1, the Ubiquitin Activating Enzyme, Reduces Drosophila Lifespan and Results in Motor Impairment

Neurodegenerative diseases cause tremendous suffering for those afflicted and their families. Many of these diseases involve accumulation of mis-folded or aggregated proteins thought to play a causal role in disease pathology. Ubiquitinated proteins are often found in these protein aggregates, and t...

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Detalles Bibliográficos
Autores principales: Liu, Hsiu-Yu, Pfleger, Cathie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558519/
https://www.ncbi.nlm.nih.gov/pubmed/23382794
http://dx.doi.org/10.1371/journal.pone.0032835