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In the hour of Sugammadex

Sugammadex is a modified gamma-cyclodextrin which is showing favorable outcomes regarding reversal of neuromuscular blockade, especially by rocuronium. It is designed to encapsulate rocuronium and being considered a new class of drugs as selective relaxant binding agents. It has given countless bene...

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Autor principal: Chon, Jin Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558646/
https://www.ncbi.nlm.nih.gov/pubmed/23372878
http://dx.doi.org/10.4097/kjae.2013.64.1.3
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author Chon, Jin Young
author_facet Chon, Jin Young
author_sort Chon, Jin Young
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description Sugammadex is a modified gamma-cyclodextrin which is showing favorable outcomes regarding reversal of neuromuscular blockade, especially by rocuronium. It is designed to encapsulate rocuronium and being considered a new class of drugs as selective relaxant binding agents. It has given countless benefits to the patients at risk of incomplete or delayed recovery after neuromuscular block and has renown for another milestone in anesthesia practice. Recurrence of neuromuscular block has not been reported to be associated with the provided doses of sugammadex that are adequate for selected for reversal. Acceptable profiles are brought to light telling safety of sugammadex. However, some questions related to the twitch characteristics those resembled succinylcholine when reversal, the application for rocuronium anaphylaxis, and the hypersensitivity or anaphylaxis to sugammadex remain and are need of further investigation. It is imperative that potential problems that we need attention may include the patient's history of pulmonary disease and allergic disease for using sugammadex.
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spelling pubmed-35586462013-01-31 In the hour of Sugammadex Chon, Jin Young Korean J Anesthesiol Review Article Sugammadex is a modified gamma-cyclodextrin which is showing favorable outcomes regarding reversal of neuromuscular blockade, especially by rocuronium. It is designed to encapsulate rocuronium and being considered a new class of drugs as selective relaxant binding agents. It has given countless benefits to the patients at risk of incomplete or delayed recovery after neuromuscular block and has renown for another milestone in anesthesia practice. Recurrence of neuromuscular block has not been reported to be associated with the provided doses of sugammadex that are adequate for selected for reversal. Acceptable profiles are brought to light telling safety of sugammadex. However, some questions related to the twitch characteristics those resembled succinylcholine when reversal, the application for rocuronium anaphylaxis, and the hypersensitivity or anaphylaxis to sugammadex remain and are need of further investigation. It is imperative that potential problems that we need attention may include the patient's history of pulmonary disease and allergic disease for using sugammadex. The Korean Society of Anesthesiologists 2013-01 2013-01-21 /pmc/articles/PMC3558646/ /pubmed/23372878 http://dx.doi.org/10.4097/kjae.2013.64.1.3 Text en Copyright © the Korean Society of Anesthesiologists, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chon, Jin Young
In the hour of Sugammadex
title In the hour of Sugammadex
title_full In the hour of Sugammadex
title_fullStr In the hour of Sugammadex
title_full_unstemmed In the hour of Sugammadex
title_short In the hour of Sugammadex
title_sort in the hour of sugammadex
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558646/
https://www.ncbi.nlm.nih.gov/pubmed/23372878
http://dx.doi.org/10.4097/kjae.2013.64.1.3
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