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The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity

BACKGROUND: The purpose of this study is to evaluate the effect of an IGK pretreatment on the cardiotoxicity of bupivacaine. METHODS: Twenty-one anesthetized mongrel dogs were randomly divided into the following three groups: the control group (CG, n = 7), the treatment group (TG, n = 7) and the pre...

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Autores principales: Kim, Jin-Tae, Yang, Sol-Mon, Lee, Kook Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558649/
https://www.ncbi.nlm.nih.gov/pubmed/23372886
http://dx.doi.org/10.4097/kjae.2013.64.1.47
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author Kim, Jin-Tae
Yang, Sol-Mon
Lee, Kook Hyun
author_facet Kim, Jin-Tae
Yang, Sol-Mon
Lee, Kook Hyun
author_sort Kim, Jin-Tae
collection PubMed
description BACKGROUND: The purpose of this study is to evaluate the effect of an IGK pretreatment on the cardiotoxicity of bupivacaine. METHODS: Twenty-one anesthetized mongrel dogs were randomly divided into the following three groups: the control group (CG, n = 7), the treatment group (TG, n = 7) and the pretreatment group (PTG, n = 7). For the 30 min of pretreatment period, CG and TG received normal saline, while PTG received an IV bolus of insulin 2 U/kg, followed by an IGK infusion (2 U/kg/hr of insulin, 0.5-1.5 g/kg/hr of glucose, 1-2 mEq/kg/hr of KCl). The bupivacaine infusion was started at the rate of 0.5 mg/kg/min in all groups after the pretreatment period. CG received normal saline only. In TG, insulin (2 U/kg) was injected simultaneously with bupivacaine infusion, followed by the IGK infusion as with PTG. The hemodynamic variables and the time duration to reach the mean arterial pressure (MAP) of 60 mmHg were compared. RESULTS: The bupivacaine infusion decreased the cardiac index, MAP, and heart rate in all three groups. Although insulin concentration was higher in TG than in PTG during bupivacaine infusion, the hemodynamic variables in PTG decreased at the slowest rate. The time taken to reach MAP of 60 mmHg in PTG, TG, and CG was 51.4 ± 8.5, 36.4 ± 9.6, and 27.1 ± 8.7 min, respectively (P < 0.05). CONCLUSIONS: IGK delays the bupivacaine-induced cardiac depression. However, a pretreatment with IGK is more effective in delaying the bupivacaine-induced hypotension than simultaneous administration, regardless of insulin concentration.
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spelling pubmed-35586492013-01-31 The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity Kim, Jin-Tae Yang, Sol-Mon Lee, Kook Hyun Korean J Anesthesiol Experimental Research Article BACKGROUND: The purpose of this study is to evaluate the effect of an IGK pretreatment on the cardiotoxicity of bupivacaine. METHODS: Twenty-one anesthetized mongrel dogs were randomly divided into the following three groups: the control group (CG, n = 7), the treatment group (TG, n = 7) and the pretreatment group (PTG, n = 7). For the 30 min of pretreatment period, CG and TG received normal saline, while PTG received an IV bolus of insulin 2 U/kg, followed by an IGK infusion (2 U/kg/hr of insulin, 0.5-1.5 g/kg/hr of glucose, 1-2 mEq/kg/hr of KCl). The bupivacaine infusion was started at the rate of 0.5 mg/kg/min in all groups after the pretreatment period. CG received normal saline only. In TG, insulin (2 U/kg) was injected simultaneously with bupivacaine infusion, followed by the IGK infusion as with PTG. The hemodynamic variables and the time duration to reach the mean arterial pressure (MAP) of 60 mmHg were compared. RESULTS: The bupivacaine infusion decreased the cardiac index, MAP, and heart rate in all three groups. Although insulin concentration was higher in TG than in PTG during bupivacaine infusion, the hemodynamic variables in PTG decreased at the slowest rate. The time taken to reach MAP of 60 mmHg in PTG, TG, and CG was 51.4 ± 8.5, 36.4 ± 9.6, and 27.1 ± 8.7 min, respectively (P < 0.05). CONCLUSIONS: IGK delays the bupivacaine-induced cardiac depression. However, a pretreatment with IGK is more effective in delaying the bupivacaine-induced hypotension than simultaneous administration, regardless of insulin concentration. The Korean Society of Anesthesiologists 2013-01 2013-01-21 /pmc/articles/PMC3558649/ /pubmed/23372886 http://dx.doi.org/10.4097/kjae.2013.64.1.47 Text en Copyright © the Korean Society of Anesthesiologists, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Experimental Research Article
Kim, Jin-Tae
Yang, Sol-Mon
Lee, Kook Hyun
The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
title The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
title_full The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
title_fullStr The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
title_full_unstemmed The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
title_short The effects of an insulin-glucose-potassium (IGK) pretreatment on the bupivacaine cardiotoxicity
title_sort effects of an insulin-glucose-potassium (igk) pretreatment on the bupivacaine cardiotoxicity
topic Experimental Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558649/
https://www.ncbi.nlm.nih.gov/pubmed/23372886
http://dx.doi.org/10.4097/kjae.2013.64.1.47
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