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Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells

Human and chimpanzee CD4+ T cells differ markedly in expression of the inhibitory receptor Siglec-5, which contributes towards differential responses to activating stimuli. While CD4+ T cells from both species are equally susceptible to HIV-1 infection, chimpanzee cells survive better, suggesting a...

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Detalles Bibliográficos
Autores principales:	Soto, Paula C., Karris, Maile Y., Spina, Celsa A., Richman, Douglas D., Varki, Ajit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558668/ https://www.ncbi.nlm.nih.gov/pubmed/22945238 http://dx.doi.org/10.1007/s00109-012-0951-7

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