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Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Discovery of Novel Akt2 Inhibitors

Akt2 is considered as a potential target for cancer therapy. In order to find novel Akt2 inhibitors which have different scaffolds, structure-based pharmacophore model and 3D-QSAR pharmacophore model were built and validated by different methods. Then, they were used for chemical databases virtual s...

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Detalles Bibliográficos
Autores principales:	Fei, Jia, Zhou, Lu, Liu, Tao, Tang, Xiang-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558715/ https://www.ncbi.nlm.nih.gov/pubmed/23372433 http://dx.doi.org/10.7150/ijms.5344

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