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Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials
The trajectory of the somatic membrane potential of a cortical neuron exactly reflects the computations performed on its afferent inputs. However, the spikes of such a neuron are a very low-dimensional and discrete projection of this continually evolving signal. We explored the possibility that the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558743/ https://www.ncbi.nlm.nih.gov/pubmed/20852625 http://dx.doi.org/10.1038/nn.2640 |
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author | Pfister, Jean-Pascal Dayan, Peter Lengyel, Máté |
author_facet | Pfister, Jean-Pascal Dayan, Peter Lengyel, Máté |
author_sort | Pfister, Jean-Pascal |
collection | PubMed |
description | The trajectory of the somatic membrane potential of a cortical neuron exactly reflects the computations performed on its afferent inputs. However, the spikes of such a neuron are a very low-dimensional and discrete projection of this continually evolving signal. We explored the possibility that the neuron’s efferent synapses perform the critical computational step of estimating the membrane potential trajectory from the spikes. We found that short-term changes in synaptic efficacy can be interpreted as implementing an optimal estimator of this trajectory. Short-term depression arose when presynaptic spiking was sufficiently intense as to reduce the uncertainty associated with the estimate; short-term facilitation reflected structural features of the statistics of the presynaptic neuron such as up and down states. Our analysis provides a unifying account of a powerful, but puzzling, form of plasticity. |
format | Online Article Text |
id | pubmed-3558743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
record_format | MEDLINE/PubMed |
spelling | pubmed-35587432013-01-30 Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials Pfister, Jean-Pascal Dayan, Peter Lengyel, Máté Nat Neurosci Article The trajectory of the somatic membrane potential of a cortical neuron exactly reflects the computations performed on its afferent inputs. However, the spikes of such a neuron are a very low-dimensional and discrete projection of this continually evolving signal. We explored the possibility that the neuron’s efferent synapses perform the critical computational step of estimating the membrane potential trajectory from the spikes. We found that short-term changes in synaptic efficacy can be interpreted as implementing an optimal estimator of this trajectory. Short-term depression arose when presynaptic spiking was sufficiently intense as to reduce the uncertainty associated with the estimate; short-term facilitation reflected structural features of the statistics of the presynaptic neuron such as up and down states. Our analysis provides a unifying account of a powerful, but puzzling, form of plasticity. 2010-09-19 2010-10 /pmc/articles/PMC3558743/ /pubmed/20852625 http://dx.doi.org/10.1038/nn.2640 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Pfister, Jean-Pascal Dayan, Peter Lengyel, Máté Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
title | Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
title_full | Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
title_fullStr | Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
title_full_unstemmed | Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
title_short | Synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
title_sort | synapses with short-term plasticity are optimal estimators of presynaptic membrane potentials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558743/ https://www.ncbi.nlm.nih.gov/pubmed/20852625 http://dx.doi.org/10.1038/nn.2640 |
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