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Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

AIM: We investigated the molecular mechanisms by which vildagliptin preserved pancreatic β cell mass and function. METHODS: Morphological, biochemical and gene expression profiles of the pancreatic islets were investigated in male KK-A(y)-TaJcl(KK-A(y)) and C57BL/6JJcl (B6) mice aged 8 weeks which r...

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Detalles Bibliográficos
Autores principales:	Hamamoto, S, Kanda, Y, Shimoda, M, Tatsumi, F, Kohara, K, Tawaramoto, K, Hashiramoto, M, Kaku, K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558804/ https://www.ncbi.nlm.nih.gov/pubmed/22950702 http://dx.doi.org/10.1111/dom.12005

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