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Highly stereocontrolled synthesis of trans-enediynes via carbocupration of fluoroalkylated diynes

Treatment of readily prepared (Z)-6-benzyloxy-1,1,1,2-tetrafluoro-6-methyl-2-hepten-4-yne with 1.5 equiv of LHMDS in −78 °C for 1 h gave the corresponding trifluoromethylated diyne in an excellent yield. This diyne was found to be a good substrate for the carbocupration with various higher-ordered c...

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Detalles Bibliográficos
Autores principales:	Konno, Tsutomu, Kishi, Misato, Ishihara, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2012
Materias:	Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558832/ https://www.ncbi.nlm.nih.gov/pubmed/23365631 http://dx.doi.org/10.3762/bjoc.8.249

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