In vitro activity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics

AFN-1252 is a novel inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits typical MIC(90) values of ⩽0·015 μg/ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. We now repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaplan, Nachum, Awrey, Donald, Bardouniotis, Elias, Berman, Judd, Yethon, Jeremy, Pauls, Henry W, Hafkin, Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Maney Publishing 2013
Materias:
Antimicrobial Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558989/
https://www.ncbi.nlm.nih.gov/pubmed/23433440
http://dx.doi.org/10.1179/1973947812Y.0000000063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558989/
https://www.ncbi.nlm.nih.gov/pubmed/23433440
http://dx.doi.org/10.1179/1973947812Y.0000000063

Ejemplares similares