In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs...

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Detalles Bibliográficos
Autores principales: Jaworski, Sławomir, Sawosz, Ewa, Grodzik, Marta, Winnicka, Anna, Prasek, Marta, Wierzbicki, Mateusz, Chwalibog, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559082/
https://www.ncbi.nlm.nih.gov/pubmed/23378763
http://dx.doi.org/10.2147/IJN.S39456
Descripción
Sumario:Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.

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