In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs...

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Autores principales: Jaworski, Sławomir, Sawosz, Ewa, Grodzik, Marta, Winnicka, Anna, Prasek, Marta, Wierzbicki, Mateusz, Chwalibog, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559082/
https://www.ncbi.nlm.nih.gov/pubmed/23378763
http://dx.doi.org/10.2147/IJN.S39456
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author Jaworski, Sławomir
Sawosz, Ewa
Grodzik, Marta
Winnicka, Anna
Prasek, Marta
Wierzbicki, Mateusz
Chwalibog, André
author_facet Jaworski, Sławomir
Sawosz, Ewa
Grodzik, Marta
Winnicka, Anna
Prasek, Marta
Wierzbicki, Mateusz
Chwalibog, André
author_sort Jaworski, Sławomir
collection PubMed
description Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.
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spelling pubmed-35590822013-02-01 In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells Jaworski, Sławomir Sawosz, Ewa Grodzik, Marta Winnicka, Anna Prasek, Marta Wierzbicki, Mateusz Chwalibog, André Int J Nanomedicine Original Research Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy. Dove Medical Press 2013 2013-01-24 /pmc/articles/PMC3559082/ /pubmed/23378763 http://dx.doi.org/10.2147/IJN.S39456 Text en © 2013 Jaworski et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Jaworski, Sławomir
Sawosz, Ewa
Grodzik, Marta
Winnicka, Anna
Prasek, Marta
Wierzbicki, Mateusz
Chwalibog, André
In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_full In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_fullStr In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_full_unstemmed In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_short In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_sort in vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559082/
https://www.ncbi.nlm.nih.gov/pubmed/23378763
http://dx.doi.org/10.2147/IJN.S39456
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