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HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina
During 2003–2009, the National Tuberculosis (TB) Laboratory Network in Argentina gave 830 patients a new diagnosis of multidrug-resistant (MDR) TB and 53 a diagnosis of extensively drug- resistant (XDR) TB. HIV co-infection was involved in nearly one third of these cases. Strain genotyping showed th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559153/ https://www.ncbi.nlm.nih.gov/pubmed/23092584 http://dx.doi.org/10.3201/eid1811.120126 |
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author | Ritacco, Viviana López, Beatriz Ambroggi, Marta Palmero, Domingo Salvadores, Bernardo Gravina, Elida Mazzeo, Eduardo Imaz, Susana Barrera, Lucía |
author_facet | Ritacco, Viviana López, Beatriz Ambroggi, Marta Palmero, Domingo Salvadores, Bernardo Gravina, Elida Mazzeo, Eduardo Imaz, Susana Barrera, Lucía |
author_sort | Ritacco, Viviana |
collection | PubMed |
description | During 2003–2009, the National Tuberculosis (TB) Laboratory Network in Argentina gave 830 patients a new diagnosis of multidrug-resistant (MDR) TB and 53 a diagnosis of extensively drug- resistant (XDR) TB. HIV co-infection was involved in nearly one third of these cases. Strain genotyping showed that 7 major clusters gathered 56% of patients within restricted geographic areas. The 3 largest clusters corresponded to epidemic MDR TB strains that have been undergoing transmission for >10 years. The indigenous M strain accounted for 29% and 40% of MDR and XDR TB cases, respectively. Drug-resistant TB trends in Argentina are driven by spread of a few strains in hotspots where the rate of HIV infection is high. To curb transmission, the national TB program is focusing stringent interventions in these areas by strengthening infection control in large hospitals and prisons, expediting drug resistance detection, and streamlining information-sharing systems between HIV and TB programs. |
format | Online Article Text |
id | pubmed-3559153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-35591532013-02-04 HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina Ritacco, Viviana López, Beatriz Ambroggi, Marta Palmero, Domingo Salvadores, Bernardo Gravina, Elida Mazzeo, Eduardo Imaz, Susana Barrera, Lucía Emerg Infect Dis Research During 2003–2009, the National Tuberculosis (TB) Laboratory Network in Argentina gave 830 patients a new diagnosis of multidrug-resistant (MDR) TB and 53 a diagnosis of extensively drug- resistant (XDR) TB. HIV co-infection was involved in nearly one third of these cases. Strain genotyping showed that 7 major clusters gathered 56% of patients within restricted geographic areas. The 3 largest clusters corresponded to epidemic MDR TB strains that have been undergoing transmission for >10 years. The indigenous M strain accounted for 29% and 40% of MDR and XDR TB cases, respectively. Drug-resistant TB trends in Argentina are driven by spread of a few strains in hotspots where the rate of HIV infection is high. To curb transmission, the national TB program is focusing stringent interventions in these areas by strengthening infection control in large hospitals and prisons, expediting drug resistance detection, and streamlining information-sharing systems between HIV and TB programs. Centers for Disease Control and Prevention 2012-11 /pmc/articles/PMC3559153/ /pubmed/23092584 http://dx.doi.org/10.3201/eid1811.120126 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Ritacco, Viviana López, Beatriz Ambroggi, Marta Palmero, Domingo Salvadores, Bernardo Gravina, Elida Mazzeo, Eduardo Imaz, Susana Barrera, Lucía HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina |
title | HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina |
title_full | HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina |
title_fullStr | HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina |
title_full_unstemmed | HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina |
title_short | HIV Infection and Geographically Bound Transmission of Drug-Resistant Tuberculosis, Argentina |
title_sort | hiv infection and geographically bound transmission of drug-resistant tuberculosis, argentina |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559153/ https://www.ncbi.nlm.nih.gov/pubmed/23092584 http://dx.doi.org/10.3201/eid1811.120126 |
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