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Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar

In October 2009, two–3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast tow...

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Autores principales: Schwarz, Norbert G., Girmann, Mirko, Randriamampionona, Njary, Bialonski, Alexandra, Maus, Deborah, Krefis, Anne Caroline, Njarasoa, Christine, Rajanalison, Jeanne Fleury, Ramandrisoa, Herly Daniel, Randriarison, Maurice Lucien, May, Jürgen, Schmidt-Chanasit, Jonas, Rakotozandrindrainy, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559170/
https://www.ncbi.nlm.nih.gov/pubmed/23092548
http://dx.doi.org/10.3201/eid1811.111036
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author Schwarz, Norbert G.
Girmann, Mirko
Randriamampionona, Njary
Bialonski, Alexandra
Maus, Deborah
Krefis, Anne Caroline
Njarasoa, Christine
Rajanalison, Jeanne Fleury
Ramandrisoa, Herly Daniel
Randriarison, Maurice Lucien
May, Jürgen
Schmidt-Chanasit, Jonas
Rakotozandrindrainy, Raphael
author_facet Schwarz, Norbert G.
Girmann, Mirko
Randriamampionona, Njary
Bialonski, Alexandra
Maus, Deborah
Krefis, Anne Caroline
Njarasoa, Christine
Rajanalison, Jeanne Fleury
Ramandrisoa, Herly Daniel
Randriarison, Maurice Lucien
May, Jürgen
Schmidt-Chanasit, Jonas
Rakotozandrindrainy, Raphael
author_sort Schwarz, Norbert G.
collection PubMed
description In October 2009, two–3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450–1,300 m high, IgG seroprevalence against CHIKV was 0%–3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission.
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spelling pubmed-35591702013-02-04 Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar Schwarz, Norbert G. Girmann, Mirko Randriamampionona, Njary Bialonski, Alexandra Maus, Deborah Krefis, Anne Caroline Njarasoa, Christine Rajanalison, Jeanne Fleury Ramandrisoa, Herly Daniel Randriarison, Maurice Lucien May, Jürgen Schmidt-Chanasit, Jonas Rakotozandrindrainy, Raphael Emerg Infect Dis Research In October 2009, two–3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450–1,300 m high, IgG seroprevalence against CHIKV was 0%–3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission. Centers for Disease Control and Prevention 2012-11 /pmc/articles/PMC3559170/ /pubmed/23092548 http://dx.doi.org/10.3201/eid1811.111036 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Schwarz, Norbert G.
Girmann, Mirko
Randriamampionona, Njary
Bialonski, Alexandra
Maus, Deborah
Krefis, Anne Caroline
Njarasoa, Christine
Rajanalison, Jeanne Fleury
Ramandrisoa, Herly Daniel
Randriarison, Maurice Lucien
May, Jürgen
Schmidt-Chanasit, Jonas
Rakotozandrindrainy, Raphael
Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar
title Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar
title_full Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar
title_fullStr Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar
title_full_unstemmed Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar
title_short Seroprevalence of Antibodies against Chikungunya, Dengue, and Rift Valley Fever Viruses after Febrile Illness Outbreak, Madagascar
title_sort seroprevalence of antibodies against chikungunya, dengue, and rift valley fever viruses after febrile illness outbreak, madagascar
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559170/
https://www.ncbi.nlm.nih.gov/pubmed/23092548
http://dx.doi.org/10.3201/eid1811.111036
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