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Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs
Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an i...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559234/ https://www.ncbi.nlm.nih.gov/pubmed/23514746 http://dx.doi.org/10.1089/biores.2012.9902 |
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author | Basel, Matthew T. Balivada, Sivasai Beck, Amanda P. Kerrigan, Maureen A. Pyle, Marla M. Dekkers, Jack C.M. Wyatt, Carol R. Rowland, Robert R.R. Anderson, David E. Bossmann, Stefan H. Troyer, Deryl L. |
author_facet | Basel, Matthew T. Balivada, Sivasai Beck, Amanda P. Kerrigan, Maureen A. Pyle, Marla M. Dekkers, Jack C.M. Wyatt, Carol R. Rowland, Robert R.R. Anderson, David E. Bossmann, Stefan H. Troyer, Deryl L. |
author_sort | Basel, Matthew T. |
collection | PubMed |
description | Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans. |
format | Online Article Text |
id | pubmed-3559234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35592342013-03-20 Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs Basel, Matthew T. Balivada, Sivasai Beck, Amanda P. Kerrigan, Maureen A. Pyle, Marla M. Dekkers, Jack C.M. Wyatt, Carol R. Rowland, Robert R.R. Anderson, David E. Bossmann, Stefan H. Troyer, Deryl L. Biores Open Access Original Research Articles Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans. Mary Ann Liebert, Inc. 2012-04 /pmc/articles/PMC3559234/ /pubmed/23514746 http://dx.doi.org/10.1089/biores.2012.9902 Text en Copyright 2012, Mary Ann Liebert, Inc. |
spellingShingle | Original Research Articles Basel, Matthew T. Balivada, Sivasai Beck, Amanda P. Kerrigan, Maureen A. Pyle, Marla M. Dekkers, Jack C.M. Wyatt, Carol R. Rowland, Robert R.R. Anderson, David E. Bossmann, Stefan H. Troyer, Deryl L. Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs |
title | Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs |
title_full | Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs |
title_fullStr | Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs |
title_full_unstemmed | Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs |
title_short | Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs |
title_sort | human xenografts are not rejected in a naturally occurring immunodeficient porcine line: a human tumor model in pigs |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559234/ https://www.ncbi.nlm.nih.gov/pubmed/23514746 http://dx.doi.org/10.1089/biores.2012.9902 |
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