Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway promotes melanoma tumor growth and survival while suppressing autophagy, a catabolic process through which cells collect and recycle cellular components to sustain energy homeostasis in starvation. Conversely...

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Detalles Bibliográficos
Autores principales: Xie, Xiaoqi, White, Eileen P., Mehnert, Janice M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559441/
https://www.ncbi.nlm.nih.gov/pubmed/23383069
http://dx.doi.org/10.1371/journal.pone.0055096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559441/
https://www.ncbi.nlm.nih.gov/pubmed/23383069
http://dx.doi.org/10.1371/journal.pone.0055096

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