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Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway promotes melanoma tumor growth and survival while suppressing autophagy, a catabolic process through which cells collect and recycle cellular components to sustain energy homeostasis in starvation. Conversely...

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Detalles Bibliográficos
Autores principales:	Xie, Xiaoqi, White, Eileen P., Mehnert, Janice M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559441/ https://www.ncbi.nlm.nih.gov/pubmed/23383069 http://dx.doi.org/10.1371/journal.pone.0055096

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