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P-Rex1 Cooperates with PDGFRβ to Drive Cellular Migration in 3D Microenvironments
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectopic expression of P-Rex1 in an immortalised human f...
Autores principales: | Campbell, Andrew D., Lawn, Samuel, McGarry, Lynn C., Welch, Heidi C., Ozanne, Bradford W., Norman, Jim C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559689/ https://www.ncbi.nlm.nih.gov/pubmed/23382862 http://dx.doi.org/10.1371/journal.pone.0053982 |
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