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Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan

Longevity has a strong genetic component evidenced by family-based studies. Lipoprotein metabolism, FOXO proteins, and insulin/IGF-1 signaling pathways in model systems have shown polygenic variations predisposing to shorter lifespan. To test the hypothesis that rare variants could influence lifespa...

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Detalles Bibliográficos
Autores principales:	Glessner, Joseph T., Smith, Albert Vernon, Panossian, Saarene, Kim, Cecilia E., Takahashi, Nagahide, Thomas, Kelly A., Wang, Fengxiang, Seidler, Kallyn, Harris, Tamara B., Launer, Lenore J., Keating, Brendan, Connolly, John, Sleiman, Patrick M. A., Buxbaum, Joseph D., Grant, Struan F. A., Gudnason, Vilmundur, Hakonarson, Hakon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559729/ https://www.ncbi.nlm.nih.gov/pubmed/23382853 http://dx.doi.org/10.1371/journal.pone.0053846

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