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Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer

BACKGROUND: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell resp...

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Autores principales: Kim, Mia, Grimmig, Tanja, Grimm, Martin, Lazariotou, Maria, Meier, Eva, Rosenwald, Andreas, Tsaur, Igor, Blaheta, Roman, Heemann, Uwe, Germer, Christoph-Thomas, Waaga-Gasser, Ana Maria, Gasser, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559740/
https://www.ncbi.nlm.nih.gov/pubmed/23382847
http://dx.doi.org/10.1371/journal.pone.0053630
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author Kim, Mia
Grimmig, Tanja
Grimm, Martin
Lazariotou, Maria
Meier, Eva
Rosenwald, Andreas
Tsaur, Igor
Blaheta, Roman
Heemann, Uwe
Germer, Christoph-Thomas
Waaga-Gasser, Ana Maria
Gasser, Martin
author_facet Kim, Mia
Grimmig, Tanja
Grimm, Martin
Lazariotou, Maria
Meier, Eva
Rosenwald, Andreas
Tsaur, Igor
Blaheta, Roman
Heemann, Uwe
Germer, Christoph-Thomas
Waaga-Gasser, Ana Maria
Gasser, Martin
author_sort Kim, Mia
collection PubMed
description BACKGROUND: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC). METHODS AND FINDINGS: Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival. CONCLUSIONS: Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression.
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spelling pubmed-35597402013-02-04 Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer Kim, Mia Grimmig, Tanja Grimm, Martin Lazariotou, Maria Meier, Eva Rosenwald, Andreas Tsaur, Igor Blaheta, Roman Heemann, Uwe Germer, Christoph-Thomas Waaga-Gasser, Ana Maria Gasser, Martin PLoS One Research Article BACKGROUND: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC). METHODS AND FINDINGS: Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival. CONCLUSIONS: Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression. Public Library of Science 2013-01-30 /pmc/articles/PMC3559740/ /pubmed/23382847 http://dx.doi.org/10.1371/journal.pone.0053630 Text en © 2013 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kim, Mia
Grimmig, Tanja
Grimm, Martin
Lazariotou, Maria
Meier, Eva
Rosenwald, Andreas
Tsaur, Igor
Blaheta, Roman
Heemann, Uwe
Germer, Christoph-Thomas
Waaga-Gasser, Ana Maria
Gasser, Martin
Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
title Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
title_full Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
title_fullStr Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
title_full_unstemmed Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
title_short Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer
title_sort expression of foxp3 in colorectal cancer but not in treg cells correlates with disease progression in patients with colorectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559740/
https://www.ncbi.nlm.nih.gov/pubmed/23382847
http://dx.doi.org/10.1371/journal.pone.0053630
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