A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration

BACKGROUND: HIV-associated dementia (HAD) is the most common dementia type in young adults less than 40 years of age. Although the neurotoxins, oxidative/metabolic stress and impaired activity of neurotrophic factors are believed to be underlying reasons for the development of HAD, the genomic basis...

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Detalles Bibliográficos
Autores principales: Zhou, Li, Pupo, Gulietta M, Gupta, Priyanka, Liu, Bing, Tran, Sieu L, Rahme, Raany, Wang, Bin, Rua, Rejane, Rizos, Helen, Carroll, Adam, Cairns, Murray J, Saksena, Nitin K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560210/
https://www.ncbi.nlm.nih.gov/pubmed/23190615
http://dx.doi.org/10.1186/1471-2164-13-677

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