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Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia
BACKGROUND: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia. However, its relevance in human endotoxemia has not been investigated so far. We thu...
Autores principales: | Padberg, Jan-Sören, Van Meurs, Matijs, Kielstein, Jan T, Martens-Lobenhoffer, Jens, Bode-Böger, Stefanie M, Zijlstra, Jan G, Kovesdy, Csaba P, Kümpers, Philipp |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560239/ https://www.ncbi.nlm.nih.gov/pubmed/23216784 http://dx.doi.org/10.1186/2040-7378-4-24 |
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