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Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

BACKGROUND: Multifactor Dimensionality Reduction (MDR) has been widely applied to detect gene-gene (GxG) interactions associated with complex diseases. Existing MDR methods summarize disease risk by a dichotomous predisposing model (high-risk/low-risk) from one optimal GxG interaction, which does no...

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Detalles Bibliográficos
Autores principales:	Dai, Hongying, Charnigo, Richard J, Becker, Mara L, Leeder, J Steven, Motsinger-Reif, Alison A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560267/ https://www.ncbi.nlm.nih.gov/pubmed/23294634 http://dx.doi.org/10.1186/1756-0381-6-1

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