Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells

AIMS: We identified an autosomal dominant non-sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC-CMs) fro...

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Detalles Bibliográficos
Autores principales: Siu, Chung-Wah, Lee, Yee-Ki, Ho, Jenny Chung-Yee, Lai, Wing-Hon, Chan, Yau-Chi, Ng, Kwong-Man, Wong, Lai-Yung, Au, Ka-Wing, Lau, Yee-Man, Zhang, Jinqiu, Lay, Kenneth Weijian, Colman, Alan, Tse, Hung-Fat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560431/
https://www.ncbi.nlm.nih.gov/pubmed/23362510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560431/
https://www.ncbi.nlm.nih.gov/pubmed/23362510

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