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Inhibition of p38 MAPK diminishes doxorubicin-induced drug resistance associated with P-glycoprotein in human leukemia K562 cells

BACKGROUND: Several studies have shown that multidrug transporters, such as P-glycoprotein (PGP), are involved in cell resistance to chemotherapy and refractory epilepsy. The p38 mitogen-activated protein kinase (MAPK) signaling pathway may increase PGP activity. However, p38-mediated drug resistanc...

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Detalles Bibliográficos
Autores principales:	Chen, Yinghui, Zhao, Yongbo, Wang, Cuicui, Xiao, Xia, Zhou, Xiaoyong, Xu, Guoxiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2012
Materias:	Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560559/ https://www.ncbi.nlm.nih.gov/pubmed/23018344 http://dx.doi.org/10.12659/MSM.883477

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