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The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury
The Na(+)/Ca(2+) exchanger (NCX) is an important electrogenic transporter in maintaining Na(+) and Ca(2+) homeostasis in a variety of mammalian organs, and is involved in the physiological and pathophysiological regulation of Ca(2+) concentration in the myocardium. It can affect cardial structure, e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560609/ https://www.ncbi.nlm.nih.gov/pubmed/23111750 http://dx.doi.org/10.12659/MSM.883533 |
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author | Chen, Sai Li, Shuzhuang |
author_facet | Chen, Sai Li, Shuzhuang |
author_sort | Chen, Sai |
collection | PubMed |
description | The Na(+)/Ca(2+) exchanger (NCX) is an important electrogenic transporter in maintaining Na(+) and Ca(2+) homeostasis in a variety of mammalian organs, and is involved in the physiological and pathophysiological regulation of Ca(2+) concentration in the myocardium. It can affect cardial structure, electrophysiology and contractile properties. The role of the NCX in heart cells following ischemia/reperfusion (IR) has been investigated using a number of in vitro and in vivo models. During ischemia, ionic disturbances favor Ca(2+)-influx mode activity as excess Na(+) is extruded in exchange for Ca(2+), giving rise to increased intracellular Ca(2+) levels (Cai). This rise in Cai contributes to reversible cellular dysfunction upon reperfusion, such as myocardial necrosis, arrhythmia, systolic dysfunction and heart failure. We have reviewed the major in vivo and in vitro cardiac IR-related NCX studies in an attempt to clarify the functions of NCX in IR and conclude that recent studies suggest blockage of NCX has potential therapeutic applications. Although the use of different IR models, application of NCX stimulators and inhibitors, and development of NCX transgenic animals do help elucidate the role of this ion exchanger in heart cells, related mechanisms are not completely understood and clinically effective specific NCX inhibitors need further research. |
format | Online Article Text |
id | pubmed-3560609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35606092013-04-24 The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury Chen, Sai Li, Shuzhuang Med Sci Monit Review Article The Na(+)/Ca(2+) exchanger (NCX) is an important electrogenic transporter in maintaining Na(+) and Ca(2+) homeostasis in a variety of mammalian organs, and is involved in the physiological and pathophysiological regulation of Ca(2+) concentration in the myocardium. It can affect cardial structure, electrophysiology and contractile properties. The role of the NCX in heart cells following ischemia/reperfusion (IR) has been investigated using a number of in vitro and in vivo models. During ischemia, ionic disturbances favor Ca(2+)-influx mode activity as excess Na(+) is extruded in exchange for Ca(2+), giving rise to increased intracellular Ca(2+) levels (Cai). This rise in Cai contributes to reversible cellular dysfunction upon reperfusion, such as myocardial necrosis, arrhythmia, systolic dysfunction and heart failure. We have reviewed the major in vivo and in vitro cardiac IR-related NCX studies in an attempt to clarify the functions of NCX in IR and conclude that recent studies suggest blockage of NCX has potential therapeutic applications. Although the use of different IR models, application of NCX stimulators and inhibitors, and development of NCX transgenic animals do help elucidate the role of this ion exchanger in heart cells, related mechanisms are not completely understood and clinically effective specific NCX inhibitors need further research. International Scientific Literature, Inc. 2012-11-01 /pmc/articles/PMC3560609/ /pubmed/23111750 http://dx.doi.org/10.12659/MSM.883533 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Review Article Chen, Sai Li, Shuzhuang The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury |
title | The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury |
title_full | The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury |
title_fullStr | The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury |
title_full_unstemmed | The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury |
title_short | The Na(+)/Ca(2+) exchanger in cardiac ischemia/reperfusion injury |
title_sort | na(+)/ca(2+) exchanger in cardiac ischemia/reperfusion injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560609/ https://www.ncbi.nlm.nih.gov/pubmed/23111750 http://dx.doi.org/10.12659/MSM.883533 |
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