Cargando…
Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
BACKGROUND: Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHOD...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560636/ https://www.ncbi.nlm.nih.gov/pubmed/22534711 http://dx.doi.org/10.12659/MSM.882737 |
_version_ | 1782257823376211968 |
---|---|
author | Jabłoński, Sławomir Brocki, Marian Krzysztof, Kujawski Wawrzycki, Marcin Santorek-Strumiłło, Edyta Łobos, Marek Kozakiewicz, Marcin |
author_facet | Jabłoński, Sławomir Brocki, Marian Krzysztof, Kujawski Wawrzycki, Marcin Santorek-Strumiłło, Edyta Łobos, Marek Kozakiewicz, Marcin |
author_sort | Jabłoński, Sławomir |
collection | PubMed |
description | BACKGROUND: Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHODS: There were 44 consecutive patients treated surgically due to AM of differentiated etiology. Selected biochemical markers (WBC, RBC, HGB, HCT, PLT, CRP, PCT, ionogram, protein and albumins) were assessed before surgery and on the 3(rd) day after surgery. ANOVA was applied to find factors influencing observations. Numerical data [laboratory parameters] were compared by means of medians. RESULTS: The overall hospital mortality rate was 31.82%. In the group of dead patients, there were observed statistically significant lower mean preoperative values of RBC [p=0.0090], HGB [p=0.0286], HCT [p=0.0354], protein [p= 0.0037], albumins [p=0.0003] and sodium [p<0.0001] and elevated values of CRP [P=0.0107] and PCT p<0.0001]. High level of inflammatory markers on day 3 after surgery was found to increase the risk of death – for WBC (by 67%), for CRP (by 88%) and for PCT (by 100%). CONCLUSIONS: Poor prognosis was more frequent in patients with preoperative high levels of CRP, PCT, anemia, hypoproteinemia and hyponatremia. The risk of death increases significantly if in the immediate postoperative period no distinct decrease in WBC count and of the CRP and PCT level is observed. In such a situation the patients should be qualified earlier for broadened diagnostic workup and for reoperation. |
format | Online Article Text |
id | pubmed-3560636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35606362013-04-24 Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis Jabłoński, Sławomir Brocki, Marian Krzysztof, Kujawski Wawrzycki, Marcin Santorek-Strumiłło, Edyta Łobos, Marek Kozakiewicz, Marcin Med Sci Monit Clinical Research BACKGROUND: Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHODS: There were 44 consecutive patients treated surgically due to AM of differentiated etiology. Selected biochemical markers (WBC, RBC, HGB, HCT, PLT, CRP, PCT, ionogram, protein and albumins) were assessed before surgery and on the 3(rd) day after surgery. ANOVA was applied to find factors influencing observations. Numerical data [laboratory parameters] were compared by means of medians. RESULTS: The overall hospital mortality rate was 31.82%. In the group of dead patients, there were observed statistically significant lower mean preoperative values of RBC [p=0.0090], HGB [p=0.0286], HCT [p=0.0354], protein [p= 0.0037], albumins [p=0.0003] and sodium [p<0.0001] and elevated values of CRP [P=0.0107] and PCT p<0.0001]. High level of inflammatory markers on day 3 after surgery was found to increase the risk of death – for WBC (by 67%), for CRP (by 88%) and for PCT (by 100%). CONCLUSIONS: Poor prognosis was more frequent in patients with preoperative high levels of CRP, PCT, anemia, hypoproteinemia and hyponatremia. The risk of death increases significantly if in the immediate postoperative period no distinct decrease in WBC count and of the CRP and PCT level is observed. In such a situation the patients should be qualified earlier for broadened diagnostic workup and for reoperation. International Scientific Literature, Inc. 2012-05-01 /pmc/articles/PMC3560636/ /pubmed/22534711 http://dx.doi.org/10.12659/MSM.882737 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Clinical Research Jabłoński, Sławomir Brocki, Marian Krzysztof, Kujawski Wawrzycki, Marcin Santorek-Strumiłło, Edyta Łobos, Marek Kozakiewicz, Marcin Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
title | Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
title_full | Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
title_fullStr | Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
title_full_unstemmed | Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
title_short | Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
title_sort | evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560636/ https://www.ncbi.nlm.nih.gov/pubmed/22534711 http://dx.doi.org/10.12659/MSM.882737 |
work_keys_str_mv | AT jabłonskisławomir evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis AT brockimarian evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis AT krzysztofkujawski evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis AT wawrzyckimarcin evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis AT santorekstrumiłłoedyta evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis AT łobosmarek evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis AT kozakiewiczmarcin evaluationofprognosticvalueofselectedbiochemicalmarkersinsurgicallytreatedpatientswithacutemediastinitis |