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Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis

BACKGROUND: Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHOD...

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Autores principales: Jabłoński, Sławomir, Brocki, Marian, Krzysztof, Kujawski, Wawrzycki, Marcin, Santorek-Strumiłło, Edyta, Łobos, Marek, Kozakiewicz, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560636/
https://www.ncbi.nlm.nih.gov/pubmed/22534711
http://dx.doi.org/10.12659/MSM.882737
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author Jabłoński, Sławomir
Brocki, Marian
Krzysztof, Kujawski
Wawrzycki, Marcin
Santorek-Strumiłło, Edyta
Łobos, Marek
Kozakiewicz, Marcin
author_facet Jabłoński, Sławomir
Brocki, Marian
Krzysztof, Kujawski
Wawrzycki, Marcin
Santorek-Strumiłło, Edyta
Łobos, Marek
Kozakiewicz, Marcin
author_sort Jabłoński, Sławomir
collection PubMed
description BACKGROUND: Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHODS: There were 44 consecutive patients treated surgically due to AM of differentiated etiology. Selected biochemical markers (WBC, RBC, HGB, HCT, PLT, CRP, PCT, ionogram, protein and albumins) were assessed before surgery and on the 3(rd) day after surgery. ANOVA was applied to find factors influencing observations. Numerical data [laboratory parameters] were compared by means of medians. RESULTS: The overall hospital mortality rate was 31.82%. In the group of dead patients, there were observed statistically significant lower mean preoperative values of RBC [p=0.0090], HGB [p=0.0286], HCT [p=0.0354], protein [p= 0.0037], albumins [p=0.0003] and sodium [p<0.0001] and elevated values of CRP [P=0.0107] and PCT p<0.0001]. High level of inflammatory markers on day 3 after surgery was found to increase the risk of death – for WBC (by 67%), for CRP (by 88%) and for PCT (by 100%). CONCLUSIONS: Poor prognosis was more frequent in patients with preoperative high levels of CRP, PCT, anemia, hypoproteinemia and hyponatremia. The risk of death increases significantly if in the immediate postoperative period no distinct decrease in WBC count and of the CRP and PCT level is observed. In such a situation the patients should be qualified earlier for broadened diagnostic workup and for reoperation.
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spelling pubmed-35606362013-04-24 Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis Jabłoński, Sławomir Brocki, Marian Krzysztof, Kujawski Wawrzycki, Marcin Santorek-Strumiłło, Edyta Łobos, Marek Kozakiewicz, Marcin Med Sci Monit Clinical Research BACKGROUND: Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHODS: There were 44 consecutive patients treated surgically due to AM of differentiated etiology. Selected biochemical markers (WBC, RBC, HGB, HCT, PLT, CRP, PCT, ionogram, protein and albumins) were assessed before surgery and on the 3(rd) day after surgery. ANOVA was applied to find factors influencing observations. Numerical data [laboratory parameters] were compared by means of medians. RESULTS: The overall hospital mortality rate was 31.82%. In the group of dead patients, there were observed statistically significant lower mean preoperative values of RBC [p=0.0090], HGB [p=0.0286], HCT [p=0.0354], protein [p= 0.0037], albumins [p=0.0003] and sodium [p<0.0001] and elevated values of CRP [P=0.0107] and PCT p<0.0001]. High level of inflammatory markers on day 3 after surgery was found to increase the risk of death – for WBC (by 67%), for CRP (by 88%) and for PCT (by 100%). CONCLUSIONS: Poor prognosis was more frequent in patients with preoperative high levels of CRP, PCT, anemia, hypoproteinemia and hyponatremia. The risk of death increases significantly if in the immediate postoperative period no distinct decrease in WBC count and of the CRP and PCT level is observed. In such a situation the patients should be qualified earlier for broadened diagnostic workup and for reoperation. International Scientific Literature, Inc. 2012-05-01 /pmc/articles/PMC3560636/ /pubmed/22534711 http://dx.doi.org/10.12659/MSM.882737 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Clinical Research
Jabłoński, Sławomir
Brocki, Marian
Krzysztof, Kujawski
Wawrzycki, Marcin
Santorek-Strumiłło, Edyta
Łobos, Marek
Kozakiewicz, Marcin
Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
title Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
title_full Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
title_fullStr Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
title_full_unstemmed Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
title_short Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
title_sort evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560636/
https://www.ncbi.nlm.nih.gov/pubmed/22534711
http://dx.doi.org/10.12659/MSM.882737
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