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Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis
BACKGROUND: This study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis. MATERIAL/METHODS: The study enrolled 285 individ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560716/ https://www.ncbi.nlm.nih.gov/pubmed/22648254 http://dx.doi.org/10.12659/MSM.882908 |
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author | Motawi, Tarek Shaker, Olfat Taha, Noha Raheem, Marwa Abdel |
author_facet | Motawi, Tarek Shaker, Olfat Taha, Noha Raheem, Marwa Abdel |
author_sort | Motawi, Tarek |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis. MATERIAL/METHODS: The study enrolled 285 individuals, classified into 4 groups: 63 cerebrovascular atherosclerotic patients, 75 cardiovascular patients, 72 peripheral atherosclerotic patients and 75 normal healthy individuals. RESULTS: The frequency of the mutant AC genotype of E-selectin in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher than in control subjects (29.17%, 28.53% and 28% vs. 8%, respectively). However, no significant difference was observed in the frequency of mutant CC allele between all atherosclerotic patients and control groups. The frequency of the mutant EE homozygotes of ICAM-1 in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher compared to controls (45.8%, 42.9% and 36% vs. 12%, respectively). The frequency of EK of ICAM-1 showed no significant difference between atherosclerotic patients and the control group. The frequency of the mutant E allele of ICAM-1 was significantly higher in peripheral, cerebral and cardiovascular patients compared to controls (58.3%, 54.8% and 54% vs. 26%, respectively). CONCLUSIONS: Ser 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis. |
format | Online Article Text |
id | pubmed-3560716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35607162013-04-24 Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis Motawi, Tarek Shaker, Olfat Taha, Noha Raheem, Marwa Abdel Med Sci Monit Clinical Research BACKGROUND: This study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis. MATERIAL/METHODS: The study enrolled 285 individuals, classified into 4 groups: 63 cerebrovascular atherosclerotic patients, 75 cardiovascular patients, 72 peripheral atherosclerotic patients and 75 normal healthy individuals. RESULTS: The frequency of the mutant AC genotype of E-selectin in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher than in control subjects (29.17%, 28.53% and 28% vs. 8%, respectively). However, no significant difference was observed in the frequency of mutant CC allele between all atherosclerotic patients and control groups. The frequency of the mutant EE homozygotes of ICAM-1 in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher compared to controls (45.8%, 42.9% and 36% vs. 12%, respectively). The frequency of EK of ICAM-1 showed no significant difference between atherosclerotic patients and the control group. The frequency of the mutant E allele of ICAM-1 was significantly higher in peripheral, cerebral and cardiovascular patients compared to controls (58.3%, 54.8% and 54% vs. 26%, respectively). CONCLUSIONS: Ser 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis. International Scientific Literature, Inc. 2012-06-01 /pmc/articles/PMC3560716/ /pubmed/22648254 http://dx.doi.org/10.12659/MSM.882908 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Clinical Research Motawi, Tarek Shaker, Olfat Taha, Noha Raheem, Marwa Abdel Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis |
title | Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis |
title_full | Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis |
title_fullStr | Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis |
title_full_unstemmed | Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis |
title_short | Genetic variations in E-selectin and ICAM-1: Relation to atherosclerosis |
title_sort | genetic variations in e-selectin and icam-1: relation to atherosclerosis |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560716/ https://www.ncbi.nlm.nih.gov/pubmed/22648254 http://dx.doi.org/10.12659/MSM.882908 |
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