Cargando…

Differences in endothelial function between Korean-Asians and Caucasians

BACKGROUND: The vascular endothelium plays an integral role in maintaining vascular homeostasis, including the regulation of blood flow, vascular tone, and platelet aggregation. The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians. MAT...

Descripción completa

Detalles Bibliográficos
Autores principales: Yim, Jongeun, Petrofsky, Jerrold, Berk, Lee, Daher, Noha, Lohman, Everett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560726/
https://www.ncbi.nlm.nih.gov/pubmed/22648248
http://dx.doi.org/10.12659/MSM.882902
_version_ 1782257844741996544
author Yim, Jongeun
Petrofsky, Jerrold
Berk, Lee
Daher, Noha
Lohman, Everett
author_facet Yim, Jongeun
Petrofsky, Jerrold
Berk, Lee
Daher, Noha
Lohman, Everett
author_sort Yim, Jongeun
collection PubMed
description BACKGROUND: The vascular endothelium plays an integral role in maintaining vascular homeostasis, including the regulation of blood flow, vascular tone, and platelet aggregation. The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians. MATERIAL/METHODS: This was accomplished by 2 measures of endothelial function – the response to local heat and the response to vascular occlusion. Ten Caucasian and 10 Korean male and female subjects participated (<35 years old). Endothelial function was assessed by the skin blood flow response to local heat using a thermode for 6 minutes at 3 temperatures (38°C, 40°C and 42°C) and by vascular occlusion for 4 minutes followed by release and measurement of skin blood flow for 2 minutes. RESULTS: When applying 6 minutes of local heat at 3 different temperatures (38°C, 40°C, and 42°C), the skin blood flows were significantly higher for all temperatures in Caucasians as compared with Koreans, with peak blood flow of 223±48.1, 413.7±132.1, and 517.4±135.8 flux in Caucasians and 126.4±41.3, 251±77.9, and 398±97.2 flux in Koreans, respectively (p=0.001). Results of this study support the idea that the skin blood flow response to occlusion was significantly higher in Caucasians (peak 411.9±88.9 flux) than Koreans (peak 332.4±75.8 flux) (p=0.016). CONCLUSIONS: These findings suggest that Koreans may have lower endothelial function than Caucasians, which may be explained, in part, by genetic variations between the 2 ethnic groups.
format Online
Article
Text
id pubmed-3560726
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-35607262013-04-24 Differences in endothelial function between Korean-Asians and Caucasians Yim, Jongeun Petrofsky, Jerrold Berk, Lee Daher, Noha Lohman, Everett Med Sci Monit Clinical Research BACKGROUND: The vascular endothelium plays an integral role in maintaining vascular homeostasis, including the regulation of blood flow, vascular tone, and platelet aggregation. The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians. MATERIAL/METHODS: This was accomplished by 2 measures of endothelial function – the response to local heat and the response to vascular occlusion. Ten Caucasian and 10 Korean male and female subjects participated (<35 years old). Endothelial function was assessed by the skin blood flow response to local heat using a thermode for 6 minutes at 3 temperatures (38°C, 40°C and 42°C) and by vascular occlusion for 4 minutes followed by release and measurement of skin blood flow for 2 minutes. RESULTS: When applying 6 minutes of local heat at 3 different temperatures (38°C, 40°C, and 42°C), the skin blood flows were significantly higher for all temperatures in Caucasians as compared with Koreans, with peak blood flow of 223±48.1, 413.7±132.1, and 517.4±135.8 flux in Caucasians and 126.4±41.3, 251±77.9, and 398±97.2 flux in Koreans, respectively (p=0.001). Results of this study support the idea that the skin blood flow response to occlusion was significantly higher in Caucasians (peak 411.9±88.9 flux) than Koreans (peak 332.4±75.8 flux) (p=0.016). CONCLUSIONS: These findings suggest that Koreans may have lower endothelial function than Caucasians, which may be explained, in part, by genetic variations between the 2 ethnic groups. International Scientific Literature, Inc. 2012-06-01 /pmc/articles/PMC3560726/ /pubmed/22648248 http://dx.doi.org/10.12659/MSM.882902 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Clinical Research
Yim, Jongeun
Petrofsky, Jerrold
Berk, Lee
Daher, Noha
Lohman, Everett
Differences in endothelial function between Korean-Asians and Caucasians
title Differences in endothelial function between Korean-Asians and Caucasians
title_full Differences in endothelial function between Korean-Asians and Caucasians
title_fullStr Differences in endothelial function between Korean-Asians and Caucasians
title_full_unstemmed Differences in endothelial function between Korean-Asians and Caucasians
title_short Differences in endothelial function between Korean-Asians and Caucasians
title_sort differences in endothelial function between korean-asians and caucasians
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560726/
https://www.ncbi.nlm.nih.gov/pubmed/22648248
http://dx.doi.org/10.12659/MSM.882902
work_keys_str_mv AT yimjongeun differencesinendothelialfunctionbetweenkoreanasiansandcaucasians
AT petrofskyjerrold differencesinendothelialfunctionbetweenkoreanasiansandcaucasians
AT berklee differencesinendothelialfunctionbetweenkoreanasiansandcaucasians
AT dahernoha differencesinendothelialfunctionbetweenkoreanasiansandcaucasians
AT lohmaneverett differencesinendothelialfunctionbetweenkoreanasiansandcaucasians