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Differences in endothelial function between Korean-Asians and Caucasians
BACKGROUND: The vascular endothelium plays an integral role in maintaining vascular homeostasis, including the regulation of blood flow, vascular tone, and platelet aggregation. The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians. MAT...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560726/ https://www.ncbi.nlm.nih.gov/pubmed/22648248 http://dx.doi.org/10.12659/MSM.882902 |
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author | Yim, Jongeun Petrofsky, Jerrold Berk, Lee Daher, Noha Lohman, Everett |
author_facet | Yim, Jongeun Petrofsky, Jerrold Berk, Lee Daher, Noha Lohman, Everett |
author_sort | Yim, Jongeun |
collection | PubMed |
description | BACKGROUND: The vascular endothelium plays an integral role in maintaining vascular homeostasis, including the regulation of blood flow, vascular tone, and platelet aggregation. The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians. MATERIAL/METHODS: This was accomplished by 2 measures of endothelial function – the response to local heat and the response to vascular occlusion. Ten Caucasian and 10 Korean male and female subjects participated (<35 years old). Endothelial function was assessed by the skin blood flow response to local heat using a thermode for 6 minutes at 3 temperatures (38°C, 40°C and 42°C) and by vascular occlusion for 4 minutes followed by release and measurement of skin blood flow for 2 minutes. RESULTS: When applying 6 minutes of local heat at 3 different temperatures (38°C, 40°C, and 42°C), the skin blood flows were significantly higher for all temperatures in Caucasians as compared with Koreans, with peak blood flow of 223±48.1, 413.7±132.1, and 517.4±135.8 flux in Caucasians and 126.4±41.3, 251±77.9, and 398±97.2 flux in Koreans, respectively (p=0.001). Results of this study support the idea that the skin blood flow response to occlusion was significantly higher in Caucasians (peak 411.9±88.9 flux) than Koreans (peak 332.4±75.8 flux) (p=0.016). CONCLUSIONS: These findings suggest that Koreans may have lower endothelial function than Caucasians, which may be explained, in part, by genetic variations between the 2 ethnic groups. |
format | Online Article Text |
id | pubmed-3560726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35607262013-04-24 Differences in endothelial function between Korean-Asians and Caucasians Yim, Jongeun Petrofsky, Jerrold Berk, Lee Daher, Noha Lohman, Everett Med Sci Monit Clinical Research BACKGROUND: The vascular endothelium plays an integral role in maintaining vascular homeostasis, including the regulation of blood flow, vascular tone, and platelet aggregation. The aim of this study was to see if there were any differences in endothelial function between Koreans and Caucasians. MATERIAL/METHODS: This was accomplished by 2 measures of endothelial function – the response to local heat and the response to vascular occlusion. Ten Caucasian and 10 Korean male and female subjects participated (<35 years old). Endothelial function was assessed by the skin blood flow response to local heat using a thermode for 6 minutes at 3 temperatures (38°C, 40°C and 42°C) and by vascular occlusion for 4 minutes followed by release and measurement of skin blood flow for 2 minutes. RESULTS: When applying 6 minutes of local heat at 3 different temperatures (38°C, 40°C, and 42°C), the skin blood flows were significantly higher for all temperatures in Caucasians as compared with Koreans, with peak blood flow of 223±48.1, 413.7±132.1, and 517.4±135.8 flux in Caucasians and 126.4±41.3, 251±77.9, and 398±97.2 flux in Koreans, respectively (p=0.001). Results of this study support the idea that the skin blood flow response to occlusion was significantly higher in Caucasians (peak 411.9±88.9 flux) than Koreans (peak 332.4±75.8 flux) (p=0.016). CONCLUSIONS: These findings suggest that Koreans may have lower endothelial function than Caucasians, which may be explained, in part, by genetic variations between the 2 ethnic groups. International Scientific Literature, Inc. 2012-06-01 /pmc/articles/PMC3560726/ /pubmed/22648248 http://dx.doi.org/10.12659/MSM.882902 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. |
spellingShingle | Clinical Research Yim, Jongeun Petrofsky, Jerrold Berk, Lee Daher, Noha Lohman, Everett Differences in endothelial function between Korean-Asians and Caucasians |
title | Differences in endothelial function between Korean-Asians and Caucasians |
title_full | Differences in endothelial function between Korean-Asians and Caucasians |
title_fullStr | Differences in endothelial function between Korean-Asians and Caucasians |
title_full_unstemmed | Differences in endothelial function between Korean-Asians and Caucasians |
title_short | Differences in endothelial function between Korean-Asians and Caucasians |
title_sort | differences in endothelial function between korean-asians and caucasians |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560726/ https://www.ncbi.nlm.nih.gov/pubmed/22648248 http://dx.doi.org/10.12659/MSM.882902 |
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