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Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma

BACKGROUND: The aim of this study was to evaluate diagnostic parameters and analysis of their advantages and limitations in early diagnostics of primary open-angle glaucoma (POAG). Cup/disc ratio (C/D), nerve fiber index (NFI) and mean deviation of retinal sensitivity (MD) were considered. MATERIAL/...

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Autores principales: Polaczek-Krupa, Barbara, Grabska-Liberek, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560767/
https://www.ncbi.nlm.nih.gov/pubmed/22739736
http://dx.doi.org/10.12659/MSM.883214
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author Polaczek-Krupa, Barbara
Grabska-Liberek, Iwona
author_facet Polaczek-Krupa, Barbara
Grabska-Liberek, Iwona
author_sort Polaczek-Krupa, Barbara
collection PubMed
description BACKGROUND: The aim of this study was to evaluate diagnostic parameters and analysis of their advantages and limitations in early diagnostics of primary open-angle glaucoma (POAG). Cup/disc ratio (C/D), nerve fiber index (NFI) and mean deviation of retinal sensitivity (MD) were considered. MATERIAL/METHODS: Fifty primary open-angle glaucoma patients (95 eyes), 67 primary open-angle glaucoma suspects (128 eyes), and 77 healthy subjects (148 eyes) underwent full ophthalmologic examination and also HRT, GDx and FDT examinations for determination of C/D, NFI, and MD parameters. Student’s t test was used to confirm the statistical significance of the differences between the particular group pairs. Histograms of distribution of the occurrence frequency of the parameter values in the groups were plotted. RESULTS: The mean values of C/D were 0.65±0.11, 0.58±0.11 and 0.43±0.11, NFI 37.0±22.7, 18.5±5.6 and 15.1±4.8 and MD −3.00±5.07, −077±2.49 and −0.29±1.94, respectively. Statistically significant differences between the particular groups were found. There was a partial overlapping of the histograms of distribution of the occurrence frequency of the parameter values. CONCLUSIONS: The basic diagnostic C/D NFI and MD parameters in primary open-angle glaucoma patients, primary open-angle glaucoma suspects and healthy subjects differed significantly. These parameters are important diagnostic tools in glaucoma diagnosis. A limitation of their applicability is related to a high scatter of the results and their overlapping in particular groups.
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spelling pubmed-35607672013-04-24 Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma Polaczek-Krupa, Barbara Grabska-Liberek, Iwona Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to evaluate diagnostic parameters and analysis of their advantages and limitations in early diagnostics of primary open-angle glaucoma (POAG). Cup/disc ratio (C/D), nerve fiber index (NFI) and mean deviation of retinal sensitivity (MD) were considered. MATERIAL/METHODS: Fifty primary open-angle glaucoma patients (95 eyes), 67 primary open-angle glaucoma suspects (128 eyes), and 77 healthy subjects (148 eyes) underwent full ophthalmologic examination and also HRT, GDx and FDT examinations for determination of C/D, NFI, and MD parameters. Student’s t test was used to confirm the statistical significance of the differences between the particular group pairs. Histograms of distribution of the occurrence frequency of the parameter values in the groups were plotted. RESULTS: The mean values of C/D were 0.65±0.11, 0.58±0.11 and 0.43±0.11, NFI 37.0±22.7, 18.5±5.6 and 15.1±4.8 and MD −3.00±5.07, −077±2.49 and −0.29±1.94, respectively. Statistically significant differences between the particular groups were found. There was a partial overlapping of the histograms of distribution of the occurrence frequency of the parameter values. CONCLUSIONS: The basic diagnostic C/D NFI and MD parameters in primary open-angle glaucoma patients, primary open-angle glaucoma suspects and healthy subjects differed significantly. These parameters are important diagnostic tools in glaucoma diagnosis. A limitation of their applicability is related to a high scatter of the results and their overlapping in particular groups. International Scientific Literature, Inc. 2012-07-01 /pmc/articles/PMC3560767/ /pubmed/22739736 http://dx.doi.org/10.12659/MSM.883214 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Clinical Research
Polaczek-Krupa, Barbara
Grabska-Liberek, Iwona
Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
title Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
title_full Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
title_fullStr Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
title_full_unstemmed Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
title_short Evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
title_sort evaluation of the significance of some diagnostic parameters in making an early diagnose of primary open-angle glaucoma
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560767/
https://www.ncbi.nlm.nih.gov/pubmed/22739736
http://dx.doi.org/10.12659/MSM.883214
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