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Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions

BACKGROUND: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that contributes to tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in human...

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Autores principales: Giaginis, Constantinos, Demetriou, Nikoleta, Alexandrou, Paraskevi, Stolakis, Vasileios, Delladetsima, Ioanna, Klijanienko, Jerzy, Griniatsos, Ioannis, Theocharis, Stamatios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560822/
https://www.ncbi.nlm.nih.gov/pubmed/22460085
http://dx.doi.org/10.12659/MSM.882613
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author Giaginis, Constantinos
Demetriou, Nikoleta
Alexandrou, Paraskevi
Stolakis, Vasileios
Delladetsima, Ioanna
Klijanienko, Jerzy
Griniatsos, Ioannis
Theocharis, Stamatios
author_facet Giaginis, Constantinos
Demetriou, Nikoleta
Alexandrou, Paraskevi
Stolakis, Vasileios
Delladetsima, Ioanna
Klijanienko, Jerzy
Griniatsos, Ioannis
Theocharis, Stamatios
author_sort Giaginis, Constantinos
collection PubMed
description BACKGROUND: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that contributes to tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in human benign and malignant thyroid lesions. MATERIAL/METHODS: RCAS1 protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 121 patients with benign and malignant lesions and was associated with type of thyroid histopathology and tumor stage parameters such as tumor size, lymph node metastases, capsular, lymphatic and vascular invasion. RESULTS: RCAS1 positivity, overexpression and staining intensity provided a distinct discrimination between benign and malignant thyroid cases (p=0.0006, p=0.0001 and p=0.0001, respectively), as well as between hyperplastic nodule and papillary carcinoma cases (p=0.0229, p=0.0001 and p=0.0001, respectively). RCAS1 positivity, overexpression and staining intensity also provided distinct discrimination between cases with Hashimoto thyroiditis and those with hyperplastic nodule (p=0.0221, p=0.0001 and p=0.0019, respectively). In the subgroup of malignant thyroid lesions, RCAS1 overexpression was significantly associated with large tumor size (p=0.0246), the presence of lymph node metastases (p=0.0351) and capsular invasion (p=0.0397). CONCLUSIONS: RCAS1 protein may participate in thyroid neoplastic transformation and could be considered as a useful biomarker to improve diagnostic scrutiny.
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spelling pubmed-35608222013-04-24 Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions Giaginis, Constantinos Demetriou, Nikoleta Alexandrou, Paraskevi Stolakis, Vasileios Delladetsima, Ioanna Klijanienko, Jerzy Griniatsos, Ioannis Theocharis, Stamatios Med Sci Monit Basic Research BACKGROUND: The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that contributes to tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in human benign and malignant thyroid lesions. MATERIAL/METHODS: RCAS1 protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 121 patients with benign and malignant lesions and was associated with type of thyroid histopathology and tumor stage parameters such as tumor size, lymph node metastases, capsular, lymphatic and vascular invasion. RESULTS: RCAS1 positivity, overexpression and staining intensity provided a distinct discrimination between benign and malignant thyroid cases (p=0.0006, p=0.0001 and p=0.0001, respectively), as well as between hyperplastic nodule and papillary carcinoma cases (p=0.0229, p=0.0001 and p=0.0001, respectively). RCAS1 positivity, overexpression and staining intensity also provided distinct discrimination between cases with Hashimoto thyroiditis and those with hyperplastic nodule (p=0.0221, p=0.0001 and p=0.0019, respectively). In the subgroup of malignant thyroid lesions, RCAS1 overexpression was significantly associated with large tumor size (p=0.0246), the presence of lymph node metastases (p=0.0351) and capsular invasion (p=0.0397). CONCLUSIONS: RCAS1 protein may participate in thyroid neoplastic transformation and could be considered as a useful biomarker to improve diagnostic scrutiny. International Scientific Literature, Inc. 2012-04-01 /pmc/articles/PMC3560822/ /pubmed/22460085 http://dx.doi.org/10.12659/MSM.882613 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Basic Research
Giaginis, Constantinos
Demetriou, Nikoleta
Alexandrou, Paraskevi
Stolakis, Vasileios
Delladetsima, Ioanna
Klijanienko, Jerzy
Griniatsos, Ioannis
Theocharis, Stamatios
Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
title Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
title_full Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
title_fullStr Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
title_full_unstemmed Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
title_short Receptor-Binding Cancer Antigen expressed on SiSo cells (RCAS1) expression in human benign and malignant thyroid lesions
title_sort receptor-binding cancer antigen expressed on siso cells (rcas1) expression in human benign and malignant thyroid lesions
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560822/
https://www.ncbi.nlm.nih.gov/pubmed/22460085
http://dx.doi.org/10.12659/MSM.882613
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