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VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue

BACKGROUND: Neoplasms are the second leading cause of death in Poland after vessel diseases, despite the huge progress in medical sciences in the last 20 years. Recently, gastric cancer morbidity has decreased, but mortality is still at a high level. MATERIAL/METHODS: Tissues from 24 patients with a...

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Autores principales: Partyka, Robert, Gonciarz, Maciej, Jałowiecki, Przemysław, Kokocińska, Danuta, Byrczek, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560834/
https://www.ncbi.nlm.nih.gov/pubmed/22460086
http://dx.doi.org/10.12659/MSM.882614
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author Partyka, Robert
Gonciarz, Maciej
Jałowiecki, Przemysław
Kokocińska, Danuta
Byrczek, Tomasz
author_facet Partyka, Robert
Gonciarz, Maciej
Jałowiecki, Przemysław
Kokocińska, Danuta
Byrczek, Tomasz
author_sort Partyka, Robert
collection PubMed
description BACKGROUND: Neoplasms are the second leading cause of death in Poland after vessel diseases, despite the huge progress in medical sciences in the last 20 years. Recently, gastric cancer morbidity has decreased, but mortality is still at a high level. MATERIAL/METHODS: Tissues from 24 patients with a histopathologically diagnosed mucosal and adenomucosal gastric cancer were tested. Patients were divided into 2 equal groups: patients without metastases (G1) and patients with metastases in the liver (G2). In all tested tissues of G1 and G2, the expression of VEGF (vascular endothelial growth factor) and metalloproteinase 2, respectively, were estimated. RESULTS: Results revealed a statistically significant increase in the VEGF expression for G1 and G2 in relation to the margin (p1<0.001; p2<0.001). The increase of gene expression for VEGF did not significantly differ statistically in G1 and G2. The obtained results revealed a statistically significant difference in the increase of gene expression for MMP-2 in G1 in relation to the margin (p<0.05) and a very high one in G2 in relation to the average margin value (p<0.001). A highly statistically significant correlation was obtained for VEGF and MMP-2 in the tissue of patients with metastases (p<0.001; r=0.714). The highly elevated expression of MMP-2 in the tissue of gastric cancer in patients with metastases confirms its participation in the invasiveness of the neoplasmatic process. CONCLUSIONS: The highly significant correlation between VEGF and MMP-2 suggests a connection between both mechanisms in the progression of gastric cancer.
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spelling pubmed-35608342013-04-24 VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue Partyka, Robert Gonciarz, Maciej Jałowiecki, Przemysław Kokocińska, Danuta Byrczek, Tomasz Med Sci Monit Basic Research BACKGROUND: Neoplasms are the second leading cause of death in Poland after vessel diseases, despite the huge progress in medical sciences in the last 20 years. Recently, gastric cancer morbidity has decreased, but mortality is still at a high level. MATERIAL/METHODS: Tissues from 24 patients with a histopathologically diagnosed mucosal and adenomucosal gastric cancer were tested. Patients were divided into 2 equal groups: patients without metastases (G1) and patients with metastases in the liver (G2). In all tested tissues of G1 and G2, the expression of VEGF (vascular endothelial growth factor) and metalloproteinase 2, respectively, were estimated. RESULTS: Results revealed a statistically significant increase in the VEGF expression for G1 and G2 in relation to the margin (p1<0.001; p2<0.001). The increase of gene expression for VEGF did not significantly differ statistically in G1 and G2. The obtained results revealed a statistically significant difference in the increase of gene expression for MMP-2 in G1 in relation to the margin (p<0.05) and a very high one in G2 in relation to the average margin value (p<0.001). A highly statistically significant correlation was obtained for VEGF and MMP-2 in the tissue of patients with metastases (p<0.001; r=0.714). The highly elevated expression of MMP-2 in the tissue of gastric cancer in patients with metastases confirms its participation in the invasiveness of the neoplasmatic process. CONCLUSIONS: The highly significant correlation between VEGF and MMP-2 suggests a connection between both mechanisms in the progression of gastric cancer. International Scientific Literature, Inc. 2012-04-01 /pmc/articles/PMC3560834/ /pubmed/22460086 http://dx.doi.org/10.12659/MSM.882614 Text en © Med Sci Monit, 2012 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
spellingShingle Basic Research
Partyka, Robert
Gonciarz, Maciej
Jałowiecki, Przemysław
Kokocińska, Danuta
Byrczek, Tomasz
VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue
title VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue
title_full VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue
title_fullStr VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue
title_full_unstemmed VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue
title_short VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue
title_sort vegf and metalloproteinase 2 (mmp 2) expression in gastric cancer tissue
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560834/
https://www.ncbi.nlm.nih.gov/pubmed/22460086
http://dx.doi.org/10.12659/MSM.882614
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