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Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine

BACKGROUND: For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. The treatment of these diseases will require detailed kn...

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Autores principales: Marko-Varga, György, Végvári, Ákos, Rezeli, Melinda, Prikk, Kaiu, Ross, Peeter, Dahlbäck, Magnus, Edula, Goutham, Sepper, Ruth, Fehniger, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560985/
https://www.ncbi.nlm.nih.gov/pubmed/23369501
http://dx.doi.org/10.1186/2001-1326-1-8
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author Marko-Varga, György
Végvári, Ákos
Rezeli, Melinda
Prikk, Kaiu
Ross, Peeter
Dahlbäck, Magnus
Edula, Goutham
Sepper, Ruth
Fehniger, Thomas E
author_facet Marko-Varga, György
Végvári, Ákos
Rezeli, Melinda
Prikk, Kaiu
Ross, Peeter
Dahlbäck, Magnus
Edula, Goutham
Sepper, Ruth
Fehniger, Thomas E
author_sort Marko-Varga, György
collection PubMed
description BACKGROUND: For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. The treatment of these diseases will require detailed knowledge of targeted pathways involved in disease pathogenesis but also the mode of drug actions at the biological location on these targets. Translational medicine is a new area of research where expert from different disciplines involved in basic science and clinical disciplines meet and join forces. Mode-of-drug-action mechanisms elucidation is key in the characterization of drugs that can relate to both efficacy and safety. METHODS: Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used providing evidence into the fate (destinations and distributions) of administered drugs within tumor regions of lung compartments. RESULTS: We hereby present a pulmonary study in which we have isolated lung tissue after inhaled drug administration and then localized the drug within airway wall compartments. The histology also provides evidence of drug binding to smooth muscle cell microenvironments. We also identified lung tissue regions with tumor cell invasion in these COPD patients. CONCLUSIONS: The ultimate goal is to identify bridging comprehension that forms a knowledge base that can be used by society to develop a better treatment and medicine for patients. Our results demonstrated that robust imaging data could be generated confirming drug localization in pulmonary regions of COPD patients with tumor pathology. TRIAL REGISTRATION: Tallinn Medical Research Ethical Committee decision #1724, 18.06.2009
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spelling pubmed-35609852013-02-04 Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine Marko-Varga, György Végvári, Ákos Rezeli, Melinda Prikk, Kaiu Ross, Peeter Dahlbäck, Magnus Edula, Goutham Sepper, Ruth Fehniger, Thomas E Clin Transl Med Research BACKGROUND: For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical intervention and early treatment. The treatment of these diseases will require detailed knowledge of targeted pathways involved in disease pathogenesis but also the mode of drug actions at the biological location on these targets. Translational medicine is a new area of research where expert from different disciplines involved in basic science and clinical disciplines meet and join forces. Mode-of-drug-action mechanisms elucidation is key in the characterization of drugs that can relate to both efficacy and safety. METHODS: Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used providing evidence into the fate (destinations and distributions) of administered drugs within tumor regions of lung compartments. RESULTS: We hereby present a pulmonary study in which we have isolated lung tissue after inhaled drug administration and then localized the drug within airway wall compartments. The histology also provides evidence of drug binding to smooth muscle cell microenvironments. We also identified lung tissue regions with tumor cell invasion in these COPD patients. CONCLUSIONS: The ultimate goal is to identify bridging comprehension that forms a knowledge base that can be used by society to develop a better treatment and medicine for patients. Our results demonstrated that robust imaging data could be generated confirming drug localization in pulmonary regions of COPD patients with tumor pathology. TRIAL REGISTRATION: Tallinn Medical Research Ethical Committee decision #1724, 18.06.2009 Springer 2012-05-31 /pmc/articles/PMC3560985/ /pubmed/23369501 http://dx.doi.org/10.1186/2001-1326-1-8 Text en Copyright ©2012 Marko-Varga et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Marko-Varga, György
Végvári, Ákos
Rezeli, Melinda
Prikk, Kaiu
Ross, Peeter
Dahlbäck, Magnus
Edula, Goutham
Sepper, Ruth
Fehniger, Thomas E
Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
title Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
title_full Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
title_fullStr Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
title_full_unstemmed Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
title_short Understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
title_sort understanding drug uptake and binding within targeted disease micro-environments in patients: a new tool for translational medicine
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560985/
https://www.ncbi.nlm.nih.gov/pubmed/23369501
http://dx.doi.org/10.1186/2001-1326-1-8
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